Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model
Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model
复制标题
DOI：
10.1142/s0192415x04002508
复制
发表时间：
2004-01-01
影响因子：
5.7
通讯作者：
Yuan, CS
中科院分区：
文献类型：
--
作者：
Mehendale, SR;Aung, HH;Yuan, CS
恶心和呕吐是顺铂等化疗药物的严重不良反应，并导致显著的患者发病率。顺铂治疗会导致氧化性肠道损伤，这被认为是恶心和呕吐的主要原因。我们用大鼠模型评价了两种抗氧化剂黄芩和西洋参对顺铂引起的恶心和呕吐的影响。大鼠对呕吐或恶心产生的刺激，如顺铂，会改变饮食习惯，表现为高岭土摄入量增加(Pica)。我们测量了大鼠的异食癖，以量化顺铂引起的恶心。我们观察到，用黄芩或人参浆果提取物对大鼠进行预处理后，顺铂诱导的PICA显著减少。本研究中观察到的中草药提取物的体外清除自由基的能力，进一步证实了该中草药的抗氧化作用。我们得出结论，草药抗氧化剂可能在减轻顺铂引起的恶心和呕吐方面发挥作用。
Nausea and vomiting are significant adverse effects of chemotherapeutic agents like cisplatin, and cause significant patient morbidity. Cisplatin treatment results in oxidant gut injury, which is postulated to be the primary cause of nausea and vomiting. We evaluated the effects of two antioxidant herbs, Scutellaria baicalensis and American ginseng berry, on cisplatin-induced nausea and vomiting using a rat model. Rats react to emetic or nausea-producing stimuli, such as cisplatin, with altered feeding habits, manifested by increased kaolin consumption (pica). We measured pica in rats to quantify cisplatin-induced nausea. We observed that pretreatment of rats with S. baicalensis or ginseng berry extracts resulted in a significant reduction in cisplatin-induced pica. The in vitro free radical scavenging ability of the herbal extract observed in the study, further confirmed the antioxidant action of the herb. We conclude that herbal antioxidants may have a role in attenuating cisplatin-induced nausea and vomiting.