Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients
Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients
复制标题
DOI：
10.1007/s10928-005-0026-2
复制
发表时间：
2005-08-01
影响因子：
2.5
通讯作者：
Eccleston, JA
中科院分区：
文献类型：
--
作者：
Waterhouse, TH;Redmann, S;Eccleston, JA
在一项研究中，主要目的之一是建立囊性纤维化患者胶囊和溶液剂量下伊曲康唑的药代动力学模型，该研究找到了最佳采样时间。最优设计有望为两种不同的结构PK模型产生可靠的总体参数估计。在这些采样时间收集的数据也有望为研究人员提供足够的信息，以合理区分这两种相互竞争的结构模型。
Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters for two different structural PK models. Data collected at these sampling times are also expected to provide the researchers with sufficient information to reasonably discriminate between the two competing structural models.