Human antibody to the group-specific polysaccharide of group B Streptococcus.
Human antibody to the group-specific polysaccharide of group B Streptococcus.
复制标题
针对 B 族链球菌的族特异性多糖的人类抗体。
DOI：
10.1093/infdis/151.2.221
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Concepcion,KF
中科院分区：
文献类型：
--
作者：
Anthony,BF;Concepcion,NF;Concepcion,KF
用特异性强、重复性好的酶联免疫吸附试验检测了106例产妇、67例健康婴儿和5例侵袭性感染成人血清中抗B群链球菌多糖IgG抗体。44名产妇携带B组链球菌的抗体浓度显著高于44名非携带者（几何平均水平分别为3.5和1.2 μg/ml）。脐带血清水平与母体血清水平密切相关。18名早发性链球菌感染婴儿母亲的血清中含有与携带者相似的水平（几何平均水平，5.5 μg/ml），并显著高于非携带者。在5名侵袭性B组链球菌感染的成人中，3名连续血清中的抗体滴度显着增加，4名抗体浓度大于大多数（93%）非携带者。这些发现表明，B组多糖在人体中具有免疫原性，并且特异性IgG抗体水平随着B组链球菌在成人中的定植或感染而增加。
IgG antibody to purified group polysaccharide of group BStreptococcuswas detected with a specific, reproducible enzyme-linked immunosorbent assay in sera of 178 human subjects: 106 parturient patients, 67 of their healthy infants, and 5 adults with invasive infection. Antibody concentrations in 44 parturient carriers of group B streptococci were significantly greater than in 44 noncarriers (geometric mean level, 3.5 and 1.2 µg/ml, respectively). Cord serum levels agreed closely with maternal serum levels. The sera of 18 mothers of infants with early-onset streptococcal infection contained levels(geometric mean level, 5.5 µg/ml) similar to those of carriers and significantly higher than noncarriers. Of five adults with invasive group B streptococcal infection, three demonstrated significant increases in antibody titer in consecutive sera, and four had antibody concentrations greater than most (93%) noncarriers. These findings suggest that group B polysaccharide is immunogenic in humans and that levels of specific IgG antibody increase with colonization or infection of adults with group B streptococci.