MOUSE PREPRO-EPIDERMAL GROWTH-FACTOR SYNTHESIS BY THE KIDNEY AND OTHER TISSUES
MOUSE PREPRO-EPIDERMAL GROWTH-FACTOR SYNTHESIS BY THE KIDNEY AND OTHER TISSUES
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DOI：
10.1038/313228a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
COGHLAN, JP
中科院分区：
文献类型：
--
作者：
RALL, LB;SCOTT, J;COGHLAN, JP
Epidermal growth factor (EGF), a protein comprising 53 amino acids, is derived from a precursor of 1,217 amino acids that includes at least seven EGF-like sequences1,2. EGF has diverse biological activities (see refs 3–6): it is a potent mitogen for many tissue culture cells, inhibits gastric acid secretion from the intestinal mucosa and promotes healing of the corneal epithelium. EGF given to fetal animals accelerates several developmental processes including palate formation, incisor eruption, eyelid opening and lung maturation. However, the physiological roles of EGFin vivoare unknown. The presence of high-affinity receptors in many fetal7and adult tissues4suggests that EGF is involved in normal cellular functions. Immunocytochemical studies have revealed the presence of EGF in mouse8and human Submaxillary glands9,10, rat brain11and human intestine9,10. The low levels of EGF in extracts from many tissues12,13may reflect sequestration rather than synthesis of the polypeptide. We show here that several mouse tissues contain preproEGF mRNA and that it is synthesized mainly in the distal tubules of the kidney. PreproEGF does not seem to be processed to EGF or other peptides in this tissue.
