OPTICAL-PROPERTIES OF NORMAL AND DISEASED HUMAN BREAST TISSUES IN THE VISIBLE AND NEAR-INFRARED
OPTICAL-PROPERTIES OF NORMAL AND DISEASED HUMAN BREAST TISSUES IN THE VISIBLE AND NEAR-INFRARED
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DOI：
10.1088/0031-9155/35/9/010
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发表时间：
1990-09-01
影响因子：
3.5
通讯作者：
FRANK, GL
中科院分区：
文献类型：
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作者：
PETERS, VG;WYMAN, DR;FRANK, GL
在500 ~ 1100 nm波长范围内测定了正常和患病人体乳腺组织标本的光吸收和散射系数。测量在切片机上切割的组织薄片的总衰减系数。使用标准积分球技术，测量这些组织的1.0 mm厚样品的漫反射率和透射率。进行蒙特卡罗模拟，以获得散射和吸收系数，以及散射角的平均余弦。结果表明，散射超过吸收至少两个数量级。吸收在低于600 nm的波长处最显著。散射系数在500 nm处在30-90 mm-1的范围内，并且随着波长的增加而平稳地下降到1100 nm处的10和50 mm-1之间。脂肪组织的散射系数不同，因为它在该光谱范围内不随波长变化。对于检查的所有组织，散射光是高度前向峰值的，散射角的平均余弦在0.945-0.985的范围内。一些组织类型的光学特性之间的系统差异被证明。
The optical absorption and scattering coefficients have been determined for specimens of normal and diseased human breast tissues over the range of wavelengths from 500 to 1100 nm. Total attenuation coefficients were measured for thin slices of tissue cut on a microtome. The diffuse reflectance and transmittance were measured for 1.0 mm thick samples of these tissues, using standard integrating sphere techniques. Monte Carlo simulations were performed to derive the scattering and absorption coefficients, as well as the mean cosine of the scattering angle. The results indicate that scatter exceeds absorption by at least two orders of magnitude. Absorption is most significant at wavelengths below 600 nm. The scattering coefficients lie in the range 30-90 mm-1 at 500 nm, and fall smoothly with increasing wavelength to between 10 and 50 mm-1 at 1100 nm. The scattering coefficient for adipose tissue differs, in that it is invariant with wavelength over this spectral range. For all tissues examined, the scattered light is highly forward peaked, with the mean cosine of the scattering angle in the range 0.945-0.985. Systematic differences between the optical properties of some tissue type are demonstrated.