The implications of medication development in the treatment of substance use disorders in developing countries
The implications of medication development in the treatment of substance use disorders in developing countries
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DOI：
10.1097/yco.0b013e32832a1dc0
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发表时间：
2009-05-01
影响因子：
6.9
通讯作者：
Chand, Prabhat K.
中科院分区：
文献类型：
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作者：
Thirthalli, Jagadisha;Chand, Prabhat K.
综述目的：探讨发展中国家药物使用障碍（sud）药物治疗的最新进展对患者的适用程度。我们回顾了有关发展中国家这一问题严重性的最新文献。然后，我们介绍了sud药物治疗的最新进展，特别是来自发展中国家的进展。最后，我们讨论了阻碍发展中国家患者从这些发展中受益的障碍。最近的调查结果在发展中国家，sud问题日益严重，而管理它的人力严重短缺。双硫仑、纳曲酮和阿坎普罗酸可用于治疗酒精依赖，同样，美沙酮和丁丙诺啡可用于治疗阿片类药物依赖。将患者与药物相匹配以及联合用药的策略显示出了希望。减少艾滋病毒在注射吸毒者中传播的风险也有同样的好处。然而，许多障碍阻碍了普通滑移患者从这些发展中受益。结论药物治疗可改善sud的预后。发展中国家在这一领域的研究正在迎头赶上。然而，由于可获得性、可负担性、人力和政府政策等问题，这些国家的大量患者无法从最近的发展中受益。迫切需要努力填补研究与实践之间的差距。
Purpose of reviewTo enquire as to how applicable are the latest developments in pharmacotherapy of substance use disorders (SUDs) to patients in developing countries. We review latest literature regarding the magnitude of the problem in developing countries. We then present a review of recent developments in pharmacotherapy of SUDs, especially from developing countries. Finally, we discuss the barriers that prevent patients in developing countries from benefiting from these developments.Recent findingsThe problem of SUDs is increasing in developing countries and there is a severe shortage of manpower to manage it. Disulfiram, naltrexone and acamprosate are useful in treating alcohol dependence, and likewise methadone and buprenorphine in treating opioid dependence. Strategies of matching patients to medications and combining the medications have shown promise. There is a parallel benefit of reduction in the risk of HIV spread among injecting drug users. However, many barriers prevent an average patient with SLID from benefiting from these developments.Conclusion Medication treatment can improve the outcome of SUDs. Research in this field is catching up in developing countries. However, due to issues of availability, affordability, manpower and governmental policies, a large number of patients in these countries are unable to benefit from recent developments. Urgent efforts are required to fill this gap between research and practice.