Thixotropy of rib cage respiratory muscles in normal subjects
Thixotropy of rib cage respiratory muscles in normal subjects
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DOI：
10.1152/jappl.2000.89.5.1753
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发表时间：
2000-11-01
影响因子：
3.3
通讯作者：
Hagbarth, KE
中科院分区：
文献类型：
--
作者：
Homma, I;Hagbarth, KE
在这项研究中，我们寻找人类胸腔呼吸肌的触变行为迹象。如果胸腔呼吸肌具有与动物和人类其他骨骼肌相似的触变特性，我们预计在深度胸腔充气或放气后，静息胸腔周长将暂时改变，并且这些后遗症在将调节深度充气或放气与呼吸肌强力等长收缩相结合的试验中尤其明显。我们使用感应体积描记法对 12 名健康受试者在安静呼吸期间的胸腔周长变化进行了连续相对测量。呼气相（EEP）结束时的胸腔位置被用作静息胸腔周长的指标。对六种调节动作前后五次自主呼吸的 EEP 值进行了比较：深吸气 (DI)；深吸气 (DI)；深度过期（DE）； DI 结合用力吸气（FID 或呼气（FEI））；DE 结合用力吸气（FIE）或呼气（FEE），两者均伴有暂时性气道闭塞。调节动作对 EEP 值的后效应与人体呼吸肌具有触变特性的假设一致。所有涉及 DI 的调节动作后，EEP 值均显着增强，并且后效在 FII 和 FEI 试验中尤为明显。相比之下，EEP DE 操作后，FEE 和 FIE 试验的后遗症显着，但 DE 试验则不然。这表明呼吸肌触变性可能导致慢性阻塞性肺病患者出现肺过度充气。
In this study, we searched for signs of thixotropic behavior in human rib cage respiratory muscles. If rib cage respiratory muscles possess thixotropic properties similar to those seen in other skeletal muscles in animals and humans, we expect resting rib cage circumference would be temporarily changed after deep rib cage inflations or deflations and that these aftereffects would be particularly pronounced in trials that combine conditioning deep inflations or deflations with forceful isometric contractions of the respiratory muscles. We used induction plethysmography to obtain a continuous relative measure of rib cage circumference changes during quiet breathing in 12 healthy subjects. Rib cage position at the end of the expiratory phase (EEP) was used as an index of resting rib cage circumference. Comparisons were made between EEP values of five spontaneous breaths immediately before and after six types of conditioning maneuvers: deep inspiration (DI); deep expiration (DE); DI combined with forceful effort to inspire (FID or expire (FEI); and DE combined with forceful effort to inspire (FIE) or expire (FEE), both with temporary airway occlusion. The aftereffects of the conditioning maneuvers on EEP values were consistent with the supposition that human respiratory muscles possess thixotropic properties. EEP values were significantly enhanced after all conditioning maneuvers involving DI, and the aftereffects were particularly pronounced in the FII and FEI trials. In contrast, EEP values were reduced after DE maneuvers. The aftereffects were statistically significant for the FEE and FIE, but not DE, trials. It is suggested that respiratory muscle thixotropy may contribute to the pulmonary hyperinflation seen in patients with chronic obstructive pulmonary disease.