3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease
3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease
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DOI：
10.1007/s00234-013-1171-8
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发表时间：
2013-06-01
期刊：
影响因子：
2.8
通讯作者：
Shirato, Hiroki
中科院分区：
文献类型：
--
作者：
Ogisu, Kimihiro;Kudo, Kohsuke;Shirato, Hiroki
神经黑素敏感MRI已被报道用于帕金森病（PD）的诊断，帕金森病是由黑质黑质（SNc）中多巴胺产生细胞的损失引起的。在本研究中，我们的目的是应用3D涡轮场回波（TFE）序列的神经黑色素敏感的MRI和评估的诊断性能的半自动方法测量SNc体积的PD患者。我们检查了18例PD患者和27名健康志愿者（对照组）。在3T扫描仪上使用具有非共振磁化转移脉冲的3D TFE技术进行神经黑色素敏感的MRI。使用区域生长技术在不同阈值（范围从1.66到2.48）下半自动测量SNc体积，测量的信号相对于上级小脑脚的信号。在所有阈值下进行受试者工作特征（ROC）分析。评价者内重复性采用组内相关系数（ICC），PD组SNc体积均小于对照组（P < 0.01，t检验）。在较高阈值（> 2.0）时，ROC曲线下面积（Az）增加（0.88）。此外，我们观察到平衡的灵敏度和特异性（分别为0.83和0.85）。在较低的阈值，敏感性往往增加，但特异性降低相比，在较高的阈值。当阈值大于1.86时，ICC大于0.9。本方法能区分PD组和对照组，具有较高的敏感性和特异性，尤其对早期PD患者。
Neuromelanin-sensitive MRI has been reported to be used in the diagnosis of Parkinson's disease (PD), which results from loss of dopamine-producing cells in the substantia nigra pars compacta (SNc). In this study, we aimed to apply a 3D turbo field echo (TFE) sequence for neuromelanin-sensitive MRI and to evaluate the diagnostic performance of semi-automated method for measurement of SNc volume in patients with PD.We examined 18 PD patients and 27 healthy volunteers (control subjects). A 3D TFE technique with off-resonance magnetization transfer pulse was used for neuromelanin-sensitive MRI on a 3T scanner. The SNc volume was semi-automatically measured using a region-growing technique at various thresholds (ranging from 1.66 to 2.48), with the signals measured relative to that for the superior cerebellar peduncle. Receiver operating characteristic (ROC) analysis was performed at all thresholds. Intra-rater reproducibility was evaluated by intraclass correlation coefficient (ICC).The average SNc volume in the PD group was significantly smaller than that in the control group at all the thresholds (P < 0.01, student t test). At higher thresholds (> 2.0), the area under the curve of ROC (Az) increased (0.88). In addition, we observed balanced sensitivity and specificity (0.83 and 0.85, respectively). At lower thresholds, sensitivity tended to increase but specificity reduced in comparison with that at higher thresholds. ICC was larger than 0.9 when the threshold was over 1.86.Our method can distinguish the PD group from the control group with high sensitivity and specificity, especially for early stage of PD.