Severity of Obstructive Sleep Apnea Syndrome and High-Sensitivity C-Reactive Protein Reduced After Relocation Pharyngoplasty
Severity of Obstructive Sleep Apnea Syndrome and High-Sensitivity C-Reactive Protein Reduced After Relocation Pharyngoplasty
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DOI：
10.1177/0194599810395104
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发表时间：
2011-04-01
影响因子：
3.4
通讯作者：
Li, Hsueh-Yu
中科院分区：
文献类型：
--
作者：
Lee, Li-Ang;Huang, Chung-Guei;Li, Hsueh-Yu
目标.目的：报告咽成形术（RP）后阻塞性睡眠呼吸暂停综合征（OSAS）的改善和高敏C反应蛋白（hs-CRP）浓度的变化，RP是悬雍垂腭咽成形术的一种高度变异。前瞻性比较研究。三级转诊中心。主题和方法。对30例既往无心血管疾病的OSAS患者进行RP治疗，分别于术前及术后6个月测定体重指数（BMI）、埃普沃思嗜睡量表（ESS）、睡眠呼吸暂停低通气指数（AHI）及血清hs-CRP水平。受试者的年龄、BMI、ESS、AHI和hs-CRP的平均值分别为39.5 ± 7.0岁、27.5 ± 4.5 kg/m2、10.8 ± 4.2、46.2 ± 22.9起事件/小时和2.06 ± 1.78 mg/L。术后6个月，RP减少了ESS（Delta = -4.3 +/- 4.5，P < .001）和AHI（Delta = -28.3 +/- 21.1，P < .001）和hs-CRP水平（Delta = -0.67 +/- 1.36，P = .012），而BMI测量结果无差异（Delta = -0.42 +/- 1.28，P = .073）。此外，极重度OSAS患者（AHI >= 60）的AHI和hs-CRP变化尤其明显。结论。尽管许多OSAS患者仍处于轻度-中度类别，但白天过度嗜睡和hs-CRP浓度降低的同等改善表明，RP后AHI的降低并不重要。
Objectives. To report improvement of obstructive sleep apnea syndrome (OSAS) and changes of high-sensitivity C-reactive protein (hs-CRP) concentrations after relocation pharyngoplasty (RP), a high variant of uvulopalatopharyngoplasty.Study Design. Prospective comparative study.Setting. Tertiary referral center.Subjects and Methods. Thirty consecutive OSAS patients without a preexisting diagnosis of cardiovascular disease who underwent RP were assessed for body mass index (BMI), Epworth Sleepiness Scale (ESS), sleep apnea-hypopnea index (AHI), and serum levels of hs-CRP at baseline and 6 months postoperatively.Results. Of the subjects, the mean values of age, BMI, ESS, AHI, and hs-CRP were 39.5 +/- 7.0 years, 27.5 +/- 4.5 kg/m(2), 10.8 +/- 4.2, 46.2 +/- 22.9 events/hour, and 2.06 +/- 1.78 mg/L, respectively. After 6 months postoperatively, RP reduced the ESS (Delta = -4.3 +/- 4.5, P < .001) and AHI (Delta = -28.3 +/- 21.1, P < .001) and levels of hs-CRP (Delta = -0.67 +/- 1.36, P = .012) significantly, whereas BMI measurements were indifferent (Delta = -0.42 +/- 1.28, P = .073). Moreover, the changes of AHI and hs-CRP were particularly remarkable in patients with very severe OSAS (AHI >= 60).Conclusion. Although many OSAS patients remain in the mild-moderate category, equivalent improvements in excessive daytime sleepiness and reductions of hs-CRP concentrations indicate that reduction of AHI is not all that matters after RP.