Serum B7-H4 expression is a significant prognostic indicator for patients with gastric cancer
Serum B7-H4 expression is a significant prognostic indicator for patients with gastric cancer
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血清B7-H4表达是胃癌患者重要的预后指标
DOI：
10.1186/1477-7819-12-188
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发表时间：
2014-06-19
影响因子：
3.2
通讯作者：
Jiang, Jingting
中科院分区：
文献类型：
--
作者：
Shi, Hongbing;Ji, Mei;Jiang, Jingting
背景B7-H4是一种新的B7配体，在T细胞介导的免疫应答中作为负调节因子发挥重要作用。以往的研究表明，肿瘤细胞中存在膜B7-H4的异常表达。方法采用双抗体夹心酶联免疫吸附试验检测132例胃癌患者和63例健康志愿者外周血中可溶性B7-H4(sB7-H4)的表达水平，探讨sB7-H4水平与胃癌患者临床病理参数及患者生存率的关系。结果胃癌患者外周血中sB7-H4浓度显著高于健康对照组(16.85vs10.46ngmL；P= 0.008)。SB7-H4的中位数与肿瘤大小、淋巴结转移、肿瘤侵袭深度和肿瘤转移类型显著相关(分别为P= 0.002，P= 0.001，P= 0.041和P&t；0.001)，而与性别、年龄、肿瘤部位和组织学分型无关(均P&>0.05)。此外，SB7-H4水平高的患者的总生存率显著低于低水平的患者(50.0%对77.3%，χ2= 10.78，P= 0.001)。多因素分析显示，SB7-H4水平高的患者死亡风险显著高于SB7-H4水平低的患者(P= 0.039)。结论B7-H4是预测胃癌患者病情进展和预后的有价值的血液标志物。
BackgroundB7-H4 is a novel B7 ligand that plays an important role in the T cell-mediated immune response as a negative regulator. Previous studies have suggested the aberrant expression of membrane B7-H4 in tumor cells. The aim of this study is to determine the expression levels of preoperative soluble B7-H4 (sB7-H4) in circulation and to investigate the correlations between sB7-H4 levels and clinicopathological parameters as well as the survival rate of patients with gastric cancer.MethodsBlood specimens from 132 patients with gastric cancer and 63 healthy volunteers were analyzed by sandwich enzyme-linked immunosorbent assay.ResultsMedian concentrations of sB7-H4 in patients with gastric cancer were significantly higher than those in healthy volunteers (16.85 versus 10.46 ng/mL;P= 0.008). Median levels of sB7-H4 were significantly correlated with tumor size, lymph node metastasis, the depth of tumor invasion and tumor-node-metastasis classification (P= 0.002,P= 0.001,P= 0.041 andP<0.001, respectively), but not with sex, age, tumor location or histological subtype (allP>0.05). Additionally, the overall survival rate was significantly lower in patients with high sB7-H4 levels when compared with low sB7-H4 levels (50.0% versus 77.3%,χ2= 10.78,P= 0.001). Moreover, multivariate analysis demonstrated that the risk of death was significantly higher in patients with high sB7-H4 levels than in those with low sB7-H4 levels (P= 0.039).ConclusionssB7-H4 is a valuable blood marker for predicting the progression and prognosis of patients with gastric cancer.