Efficacy of Indigo Naturalis Therapy for Ulcerative Colitis: A Case Series
Efficacy of Indigo Naturalis Therapy for Ulcerative Colitis: A Case Series
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DOI：
10.2169/internalmedicine.2446-18
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发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Matsumoto, Takayuki
中科院分区：
文献类型：
--
作者：
Urushikubo, Jun;Yanai, Shunichi;Matsumoto, Takayuki
目的靛蓝（Indigo naturalis，IN）是近年来报道的治疗溃疡性结肠炎（UC）的有效中药。方法回顾性分析2015年10月至2016年12月14例接受IN治疗的UC患者。结果口服IN 8周后，部分马约评分从4（2 - 5）降至1.5（0 - 4）[中位数，四分位距（IQR），p = 0.015]。在10例活动性UC患者中，5例（50%）显示临床应答，4例（40%）达到临床缓解。使用马约内镜分项评分（MES）、Rachmilewitz内镜指数（REI）评价9例患者内镜活动的系列变化。和UC内镜严重程度指数（UCEIS）。MES从2（2 - 3）降至1（1 - 2）[中位数（IQR），p = 0.005]，REI从7（5.5 - 11）降至3（1 - 7）[中位数（IQR），p = 0.008]。UCEIS从3（3 - 4.5）降至1（0.5 - 3.5）[中位数（IQR），p = 0.039]。1例患者发生急性右侧结肠炎，肠壁增厚和水肿的变化，其余13例无不良事件。结论我们得出结论，IN是有效的UC患者作为诱导缓解的治疗。
Objective Indigo naturalis (IN) is a traditional Chinese medicine that has recently been reported to be effective for ulcerative colitis (UC). The aim of this study was to evaluate the efficacy and safety of IN.Methods We performed a retrospective observational study for 14 patients with UC treated with IN from October 2015 to December 2016.Results After 8 weeks of oral administration of IN, the partial Mayo score decreased from 4 (2-5) to 1.5 (0-4) [median, interquartile range (IQR), p=0.015]. Among 10 active UC patients, 5 (50%) showed a clinical response, and 4 (40%) achieved clinical remission. Serial changes of endoscopic activity were evaluated in nine patients using the Mayo endoscopic subscore (MES), Rachmilewitz endoscopic index (REI). and UC endoscopy index of severity (UCEIS). The MES decreased from 2 (2-3) to 1 (1-2) [median (IQR), p=0.005], the REI decreased from 7 (5.5-11) to 3 (1-7) [median (IQR), p=0.008]. and the UCEIS decreased from 3 (3-4.5) to 1 (0.5-3.5) [median (IQR), p=0.039]. One patient developed acute right-sided colitis with wall thickening and edematous change, and the remaining 13 showed no adverse events.Conclusion We conclude that IN is effective for patients with UC as a therapy for inducing remission.