Neuronal circuits for fear and anxiety
Neuronal circuits for fear and anxiety
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DOI：
10.1038/nrn3984
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发表时间：
2015-06
影响因子：
34.7
通讯作者：
P. Tovote;J. Fadok;A. Lüthi
中科院分区：
文献类型：
--
作者：
P. Tovote;J. Fadok;A. Lüthi
报告Philip Tovote， Jonathan Paul Fadok和Andreas l<s:1> thi在“恐惧和焦虑的神经回路”中的错误（Nature Reviews Neuroscience, 2015 [Jun], Vol 16[6], 317-331）。在本文图4的关键中，标签“促进恐惧”和“抑制恐惧”应该分别是“促进焦虑”和“抑制焦虑”。文章已在网上更正。（以下原文摘要见记录2015-23339-006）几十年的研究已经确定了与恐惧、恐惧消退、焦虑和相关防御行为有关的大脑区域。新开发的遗传和病毒工具、光遗传学和先进的体内成像技术现在已经可以表征复杂神经元回路中特定细胞类型的活性、连通性和功能。最近使用这些工具和技术的发现，为内部防御状态下电路的精妙组织提供了机制上的见解。这篇综述的重点是使用基于回路的方法来获得更详细、更全面、更综合的关于大脑如何控制恐惧和焦虑以及如何协调适应性防御行为的观点的研究。（PsycINFO数据库记录(c) 2017 APA，版权所有）
Reports an error in" Neuronal circuits for fear and anxiety" by Philip Tovote, Jonathan Paul Fadok and Andreas Lüthi (Nature Reviews Neuroscience, 2015 [Jun], Vol 16 [6], 317-331). In the key for Figure 4 of this article, the labels' promotes fear'and'dampens fear'should have been'promotes anxiety'and'dampens anxiety', respectively. The article has been corrected online.(The following abstract of the original article appeared in record 2015-23339-006). Decades of research has identified the brain areas that are involved in fear, fear extinction, anxiety and related defensive behaviours. Newly developed genetic and viral tools, optogenetics and advanced in vivo imaging techniques have now made it possible to characterize the activity, connectivity and function of specific cell types within complex neuronal circuits. Recent findings that have been made using these tools and techniques have provided mechanistic insights into the exquisite organization of the circuitry underlying internal defensive states. This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.(PsycINFO Database Record (c) 2017 APA, all rights reserved)