Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma
Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma
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DOI：
10.1006/cyto.2002.1993
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发表时间：
2002-11-24
期刊：
影响因子：
3.8
通讯作者：
Icli, F
中科院分区：
文献类型：
--
作者：
Akbulut, H;Altuntas, F;Icli, F
近年来，血管生成作为多种实体肿瘤的预后因素已引起越来越多的关注。在这项研究中，我们旨在评估血清血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（b-FGF）和一氧化氮（NO）水平在结直肠癌（CRC）患者中的预后作用。共纳入52例I至IV期连续结直肠癌患者。除了常规的实验室和分期程序外，还检测了血清VEGF、b-FGF水平和硝酸盐水平（作为体内NO生成的替代标志物）。单因素分析发现，血清VEGF浓度（经血小板计数调整）是影响总生存率的重要因素（P = 0.033）。建立了一种新的血管生成指数（AI），该指数来源于血清VEGF和硝酸盐浓度。AI是所有患者生存的唯一独立预后因素（P = 0.008， Cox回归分析）。同样，人工智能也是可手术结直肠癌患者无病生存（DFS）的重要预后因素（P = 0.032， Cox回归分析）。综上所述，血清VEGF和NO水平在结直肠癌患者的预后中具有重要作用，用血清VEGF和NO水平作为新的血管生成指数似乎是有用的。(C) 2002 Elsevier Science Ltd.版权所有。
Recently, angiogenesis has gained an increasing interest as a prognostic factor in a variety of solid tumours. In this study we aimed to assess the prognostic role of serum vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF) and nitric oxide (NO) levels in patients with colorectal carcinoma (CRC).A total of 52 consecutive colorectal cancer patients with stage I to IV disease was included. In addition to routine laboratory and staging procedures, serum VEGF, b-FGF levels, and nitrate levels as a surrogate marker for in-vivo NO production were assayed.Serum VEGF concentrations, adjusted to the platelet count were found to be a significant factor for overall survival in univariate analysis (P = 0.033). A new angiogenic index (AI), derived from serum VEGF and nitrate concentrations, was established. AI is the only independent prognostic factor of survival in all patients (P = 0.008, Cox regression analysis). Likewise, AI is also significant prognostic factor for disease-free survival (DFS) in patients with operable CRC (P = 0.032, Cox regression analysis).In conclusion, serum VEGF and NO levels have prognostic role in patients with CRC and the new angiogenesis index using the serum levels of the factors seem to be useful. (C) 2002 Elsevier Science Ltd. All rights reserved.