Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.
Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.
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DOI：
10.18632/oncotarget.21515
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发表时间：
2017-11-03
期刊：
影响因子：
--
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Cai H;Wang Y;He J;Cai T;Wu J;Fang J;Zhang R;Guo Z;Guan L;Zhan Q;Lin L;Xiao Y;Pan H;Wang Q
阿尔茨海默病(AD)是一种进行性神经退行性疾病。阿尔茨海默病的主要临床表现为进行性认知障碍和人格改变。老年斑、神经炎症和突触结构稳定性破坏是AD的主要病理特征。八角甲素(BJJS)是从中草药巴戟天中提取的。本研究在APPsWE/PSEN1ΔE9(APP/PS1)双转基因小鼠上，从多方面探讨补肾健脑冲剂对AD的影响。Morris水迷宫实验和新物体识别实验结果表明，补肾健脑散能明显改善APP/PS1小鼠的学习记忆能力。补肾健脑冲剂能提高APP/PS1小鼠脑内胰岛素降解酶和脑活素的水平，降低β位点APP裂解酶1的水平。补肾健脑冲剂治疗的APP/PS1小鼠Aβ沉积减少，衰老斑块减少，脑内神经营养因子水平升高。我们还发现补肾健脾散对APP/PS1小鼠的神经炎症有抑制作用。此外，BJJS治疗后APP/PS1小鼠脑内突触结构相关蛋白表达上调。提示补肾健脑汤可通过改善APP/PS1小鼠AD相关的病理改变而减轻认知功能障碍。这些发现表明，补阳还五汤可能是阿尔茨海默病的一种潜在的治疗策略。
Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed that BJJS could significantly improve the learning and memory abilities in APP/PS1 mice. BJJS treatment increased the level of insulin degradation enzyme (IDE) and neprilysin (NEP) and decreased the level of β-site app cleaving enzyme 1(BACE1) in the brain of APP/PS1 mice. BJJS-treated APP/PS1 mice appeared to have reductions of Aβ deposition and senile plaques, and showed higher levels of neurotrophic factors in the brain. We also found that BJJS had an inhibitory function on neuroinflammation in APP/PS1 mice. In addition, the synapse structure relevant proteins were elevated in the brain of BJJS-treated APP/PS1 mice. The present results indicated that BJJS could attenuate cognitive impairment via ameliorating the AD-related pathological alterations in APP/PS1 mice. These findings suggest that BJJS may be a potential therapeutic strategy in Alzheimer's disease.
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