Intravesical resiniferatoxin versus botulinum-A toxin injections for neurogenic detrusor overactivity: A prospective randomized study
Intravesical resiniferatoxin versus botulinum-A toxin injections for neurogenic detrusor overactivity: A prospective randomized study
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DOI：
10.1097/01.ju.0000132152.53532.5d
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发表时间：
2004-07-01
影响因子：
6.6
通讯作者：
Porena, M
中科院分区：
文献类型：
--
作者：
Giannantoni, A;Di Stasi, SM;Porena, M
目的：我们研究了膀胱内树脂毒素（Sigma Chemical Co.，密苏里州圣路易斯）和肉毒杆菌-A 毒素注射到一组对传统抗胆碱能治疗无反应的神经源性逼尿肌过度活动的脊髓损伤患者的逼尿肌中的有效性和安全性。材料和方法：总共 25 名患者被随机分配接受膀胱内注射 0.6 muM 树脂毒素，每组 50 名ml 0.9% NaCl 或将稀释在 30 ml 0.9% NaCl 中的 300 单位 A 型肉毒杆菌毒素注射到逼尿肌中。在基线以及治疗后 6、12 和 18 个月时进行临床评估和尿动力学检查。 结果：在 6、12 和 18 个月的随访中，两组的导尿次数和失禁发作次数均显着减少，首次逼尿肌收缩和最大膀胱容量显着增加。两种治疗均未出现局部副作用。 A 型肉毒杆菌毒素可显着降低每日失禁发作的频率 (p
Purpose: We investigated the effectiveness and safety of intravesical resiniferatoxin (Sigma Chemical Co., St. Louis, Missouri) and botulinum-A toxin injections into the detrusor muscle in a group of spinal cord injured patients with neurogenic detrusor overactivity unresponsive to conventional anticholinergic therapy.Materials and Methods: A total of 25 patients were randomly assigned to receive intravesically 0.6 muM resiniferatoxin in 50 ml of 0.9% NaCl or injections into the detrusor muscle of 300 units botulinum A-toxin diluted in 30 ml 0.9% NaCl. Clinical evaluation and urodynamics were performed at baseline, and at 6, 12 and 18 months after treatment.Results: In both arms there was a significant decrease in catheterization and incontinent episodes, and a significant increase in first detrusor contraction and maximum bladder capacity at 6, 12 and 18-month followup. There were no local side effects with either treatment. Botulinum-A toxin induced a significant decrease in the frequency of daily incontinence episodes (p