Can the Behaviour Abnormalities Induced by Gestational Stress in Rats be Prevented or Reversed?
Can the Behaviour Abnormalities Induced by Gestational Stress in Rats be Prevented or Reversed?
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妊娠应激引起的大鼠行为异常可以预防或逆转吗？
DOI：
10.1080/1025389021000010503
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发表时间：
2002
期刊：
影响因子：
2.3
通讯作者：
M. Weinstock
中科院分区：
文献类型：
--
作者：
M. Weinstock
妊娠应激增加了循环中的母体荷尔蒙，这些荷尔蒙会导致行为变化，并损害后代下丘脑-垂体-肾上腺轴的反馈调节。与对照组相比，产前应激(PS)大鼠在边缘系统对刺激的反应也释放更多促肾上腺皮质激素(CRH)。这导致他们对令人畏惧的情况和类似抑郁的行为有夸大的恐惧。通过对怀孕母亲、新生儿或成年后代进行不同的治疗，可以更多地了解妊娠应激导致行为异常的潜在机制。这些治疗中的许多也能够预防或逆转异常。这些措施包括母亲肾上腺切除和更换基础激素水平以避免血浆皮质酮长期升高，给予抗焦虑药物以减少她对压力的反应，以及持续阻断阿片受体以防止胎儿阿片系统下调和随后的行为改变。如果作为新生儿的成年PS子代每天处理10天，或在青春期前给予抗抑郁药阿米替林4-5周，也可以避免成年PS子代的过度焦虑。成年PS大鼠对新奇事物的恐惧增加也可以通过脑室注射CRH拮抗剂来消除。这表明，进入大脑的新的非肽CRH1受体拮抗剂可能为因妊娠应激而引起的后代行为异常提供有效的治疗。
Gestational stress increases circulating maternal hormones that produce changes in behaviour and impair the feedback regulation of the hypothalamic pituitary adrenal axis of the offspring. Prenatally-stressed (PS) rats also release more corticotropin-releasing hormone (CRH) in the limbic system in response to stimulation than controls. This contributes to their exaggerated fear of intimidating situations and depressive-like behaviour. By using different treatments given to the pregnant mother, to neonatal or adult offspring, it has been possible to learn more about the mechanisms underlying the behavioural abnormalities induced by gestational stress. Many of these treatments were also able to prevent or reverse the abnormalities. They included maternal adrenalectomy and replacement of her basal hormone levels to avoid the prolonged elevation of plasma corticosterone, administration of anti-anxiety agents to reduce her reactions to the stress and continuous blockade of opioid receptors to prevent down-regulation of the foetal opioid system and subsequent alterations in behaviour. Hyperanxiety in the adult PS offspring could also be avoided if, as neonates, they were handled daily for 10 days, or given an antidepressant, amitriptyline for 4-5 weeks in the prepubertal period. Increased fear of novelty in adult PS rats could also be abolished by the intracerebro-ventricular administration of a CRH antagonist. This suggests that the new non-peptide CRH1 receptor antagonists that enter the brain might provide an effective treatment for the behaviour abnormalities in the offspring arising as a result of gestational stress.
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影响因子：
1.9
作者：
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影响因子：
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作者：
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影响因子：
1.9
作者：
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DOI：
--
发表时间：
1990
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Yang,XM;Gorman,AL;Dunn,AJ
通讯作者：
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