Levonorgestrel-impregnated Intrauterine device reduces occurrence of hyperplastic polyps: a population-based follow-up cohort study.
Levonorgestrel-impregnated Intrauterine device reduces occurrence of hyperplastic polyps: a population-based follow-up cohort study.
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发表时间：
2014-05
影响因子：
2
通讯作者：
M. Årnes;B. Hvingel;A. Orbo
中科院分区：
文献类型：
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作者：
M. Årnes;B. Hvingel;A. Orbo
背景：研究的主要目的是探讨左旋诺孕酮宫内植入系统(LNG-IUS，Mirena®；Bayer)是否能减少增生性息肉的发生，以及LNG-IUS是否比口服醋酸甲羟孕酮(MPA)或仅观察更有效。方法59例增生性息肉患者接受LNG-IUS治疗，10 mg口服甲孕酮，10天为一周期，或仅观察6个月。在治疗前和治疗6个月后，光镜下根据WHO分级和D评分进行组织学标本的诊断。结果LNG-IUS组未发现息肉(18/18)。治疗6个月后，5例(5/20，25%)和2例(2/21，9%)观察组子宫内膜正常，无息肉。结论LNG-IUS可有效减少增生性子宫内膜息肉的发生。其疗效优于口服黄体酮和单纯观察组。
BACKGROUND The main objective was to investigate if occurrence of hyperplastic polyps was reduced by use of the levonorgestrel-impregnated intrauterine system (LNG-IUS, Mirena®; Bayer) and if the LNG-IUS was more effective compared to oral medroxyprogesterone acetate (MPA) or observation-only. PATIENTS AND METHODS Patients (N=59) with hyperplastic polyps were given LNG-IUS, 10 mg oral MPA taken 10 days per cycle, or had observation-only for six months. Diagnosis of histological specimens was performed by light microscopy according to the WHO classification and D-score prior to and after six months therapy. RESULTS No polyps were found in women treated with LNG-IUS (18/18). Five women treated with cyclic MPA (5/20, 25%) and two (2/21, 9%) with observation had normal endometrium without polyps after six months. CONCLUSION No former study has shown that LNG-IUS is effective at reducing the occurrence of hyperplastic endometrial polyps. The effect is superior to that of oral progestin and observation-only.