Neuronal Avalanches in Spontaneous Activity In Vivo
Neuronal Avalanches in Spontaneous Activity In Vivo
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DOI：
10.1152/jn.00953.2009
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发表时间：
2010-12-01
影响因子：
2.5
通讯作者：
Nikolic, Danko
中科院分区：
文献类型：
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作者：
Hahn, Gerald;Petermann, Thomas;Nikolic, Danko
Hahn G，Petermann T，Havenith MN，Yu S，Singer W，Plenz D，Nikolic D.在体自发活动中的神经元雪崩。J Neurophysiol 104：3312-3322，2010.首次发表于2010年7月14日; doi：10.1152/jn.00953.2009。许多复杂的系统会产生在空间和时间上聚集的事件，从而建立一个由幂律统计控制的相关结构。在皮质中，最近在急性皮质切片、切片培养物、麻醉大鼠发育中的皮质以及清醒猴子的运动前区和运动皮质的自发活动的局部场电位（LFP）中发现了这种称为“神经元雪崩”的活动簇。目前，尚不清楚神经元雪崩是否也存在于成熟大脑的感觉区的自发LFP和棘波活动中。为了解决这个问题，我们记录了自发的LFP和细胞外尖峰活动与多个4 × 4微电极阵列（密歇根探针）在17区的成年猫麻醉。事件簇被定义为时间仓Δ t（1-32 ms）的连续序列，每个时间仓包含阵列上任何位置的至少一个LFP事件或尖峰。LFP簇大小一致地根据幂律分布，斜率在很大程度上大于-1.5。在三分之二的相应实验中，尖峰簇也显示出幂律，其斜率略陡，为-1.8，并被二次采样操作破坏。与缺乏幂律统计的尖峰簇相比，尖峰簇中的幂律伴随着跨越更长时间段的神经元的尖峰活动之间更强的时间相关性。结果表明，麻醉状态下视皮层的自发活动具有神经元雪崩的性质。
Hahn G, Petermann T, Havenith MN, Yu S, Singer W, Plenz D, Nikolic D. Neuronal avalanches in spontaneous activity in vivo. J Neurophysiol 104: 3312-3322, 2010. First published July 14, 2010; doi:10.1152/jn.00953.2009. Many complex systems give rise to events that are clustered in space and time, thereby establishing a correlation structure that is governed by power law statistics. In the cortex, such clusters of activity, called "neuronal avalanches," were recently found in local field potentials (LFPs) of spontaneous activity in acute cortex slices, slice cultures, the developing cortex of the anesthetized rat, and premotor and motor cortex of awake monkeys. At present, it is unclear whether neuronal avalanches also exist in the spontaneous LFPs and spike activity in vivo in sensory areas of the mature brain. To address this question, we recorded spontaneous LFPs and extracellular spiking activity with multiple 4 x 4 microelectrode arrays (Michigan Probes) in area 17 of adult cats under anesthesia. A cluster of events was defined as a consecutive sequence of time bins Delta t (1-32 ms), each containing at least one LFP event or spike anywhere on the array. LFP cluster sizes consistently distributed according to a power law with a slope largely above -1.5. In two thirds of the corresponding experiments, spike clusters also displayed a power law that displayed a slightly steeper slope of -1.8 and was destroyed by subsampling operations. The power law in spike clusters was accompanied with stronger temporal correlations between spiking activities of neurons that spanned longer time periods compared with spike clusters lacking power law statistics. The results suggest that spontaneous activity of the visual cortex under anesthesia has the properties of neuronal avalanches.