Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat
Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat
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DOI：
10.1006/phrs.2001.0877
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发表时间：
2001-12-01
影响因子：
9.3
通讯作者：
Altas, S
中科院分区：
文献类型：
--
作者：
Bilici, D;Akpinar, E;Altas, S
本文的目的是研究t型钙通道阻滞剂对急性局部炎症（组胺诱导）模型的保护作用。足底注射组胺引起炎症反应，其特征是足部水肿和足部组织中性粒细胞浸润的时间依赖性增加。组胺给药后90 min，大鼠足部体积增加最大（最大足部体积：0.97±0.07）。此外，多态核白细胞（PNL）数量在组胺处理后显著增加（144 +/- 25.56）。然而，在注射组胺后30、60、90、120、150、180分钟，米贝弗拉迪（分别给予10、25、50和100 mg kg(-1)）治疗组胺诱导的足跖水肿，以剂量依赖的方式显著减少。米贝替拉治疗也引起爪组织中多形核白细胞数量的显著减少。我们的研究结果支持米贝弗拉迪具有抗炎作用的观点。(C) 2001学术出版社。
The aim of this paper was to investigate the protective effect of the T-type calcium channel blocker in a model of acute local inflammation (histamine-induced). The intraplantar injection of histamine elicited an inflammatory response that was characterized by a time-dependent increase in paw oedema and neutrophil infiltration in paw tissue. The maximal increase in paw volume was observed at 90 min after histamine administration (maximal paw volume: 0.97 +/- 0.07). In addition, polymorphonuclear leucocyte (PNL) number was markedly increased in the histamine-treated paw tissue (144 +/- 25.56). However, histamine-induced paw oedema was significantly reduced in a dose-dependent manner by treatment with mibefradil (given at 10, 25, 50, and 100 mg kg(-1)) at 30, 60, 90, 120, 150, 180 min after injection of histamine. Mibefradil treatment also caused a significant reduction of the polymorphonuclear leucocyte number in the paw tissue. Our findings support the view that mibefradil exerts antiinflammatory effects. (C) 2001 Academic Press.