A VTA GABAergic neural circuit mediates visually evoked innate de- 1 A VTA GABAergic neural circuit mediates visually evoked innate defensive responses
A VTA GABAergic neural circuit mediates visually evoked innate de- 1 A VTA GABAergic neural circuit mediates visually evoked innate defensive responses
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VTA GABA 能神经回路介导视觉诱发的先天防御反应 1 VTA GABA 能神经回路介导视觉诱发的先天防御反应
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Liping Wang
中科院分区：
文献类型：
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作者：
Zheng Zhou;Xuemei Liu;Shanping Chen;Zhijian Zhang;Yuanming Liu;Quentin Montardy;Yongqiang Tang;Pengfei Wei;Nan Liu;Lei Li;Xiaobin He;Chen Chen;Guoqiang Bi;Guoping Feng;Fuqiang Xu;Liping Wang
Innate defensive responses are essential for animal survival and are conserved.38 across species. The ventral tegmental area (VTA) plays important roles in learned ap39.petitive and aversive behaviors, but whether it plays a role in mediating or modulating.40 innate defensive responses is currently unknown. We report that GABAergic neurons.41 in the mouse VTA (VTAGABA+) are preferentially activated compared to VTA dopa42.minergic (VTADA+) neurons when a threatening visual stimulus evokes innate defen43.sive behavior. Functional manipulation of these neurons showed that activation of.44 VTAGABA+ neurons is indispensable for looming-evoked defensive flight behavior and.45 photoactivation of these neurons is sufficient for looming-evoked defensive-like flight.46 behavior, whereas no such role can be attributed for VTADA+ neurons. Viral tracing.47 and in vivo and in vitro electrophysiological recordings showed that VTAGABA+ neu48.rons receive direct excitatory inputs from the superior colliculus (SC). Furthermore,.49 we showed that glutamatergic SC-VTA projections synapse onto VTAGABA+ neurons.50 that project to the central nucleus of the amygdala (CeA) and that the CeA is involved.51 in mediating the defensive behavior. Our findings demonstrate that visual information.52 about aerial threats access to the VTAGABA+ neurons mediating innate behavioral re53.sponses, suggesting a more general role for the VTA.这是论文在preprint预印版在线发表，与传统的期刊论文发表不同。因为成果库录入的选项里面暂时没有预印版的模板，所以借助期刊论文的表格上传。如需要修改，敬请通知，感谢。