Benign lymphangioendothelioma: a clinical, histopathologic and immunohistochemical analysis of four cases
Benign lymphangioendothelioma: a clinical, histopathologic and immunohistochemical analysis of four cases
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DOI：
10.1111/cup.12216
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发表时间：
2013-11-01
影响因子：
1.7
通讯作者：
Wang, Gang
中科院分区：
文献类型：
--
作者：
Wang, Lei;Chen, Liuqing;Wang, Gang
背景良性淋巴管内皮瘤是一种罕见的淋巴管增生，其特征是真皮胶原纤维间的不规则薄壁血管增生。免疫组化分析一直缺乏在大多数以前报道的cases. MethodsHere，我们报告的临床和组织病理学特征的4例良性淋巴管内皮瘤。所有病变均行免疫组化染色。3处病变位于大腿，1处病变位于颈部。组织学上，所有病变均显示吻合或网状薄壁血管增生，单层内皮细胞剥离真皮。D2-40、Prox 1免疫组化染色均为阳性，Wilms tumor 1（WT-1）免疫组化染色均为阴性。WT-1表达的缺乏表明其代表淋巴管畸形。
BackgroundBenign lymphangioendothelioma represents a rare lymphatic vascular proliferation characterized by proliferation of irregular and thin-walled vessels dissecting amongst dermal collagen. Immunohistochemical analysis has been lacking in most previously reported cases.MethodsHerein, we report the clinical and histopathologic characteristics of four cases of benign lymphangioendothelioma. Immunohistochemical study was completed for all lesions.ResultsAll lesions presented as large, red to brown patches or plaques. Three lesions were located on the thigh and one lesion was located on the neck. Histopathologically, all lesions showed proliferation of anastomotic or retiform thin-walled vessels with a single layer of endothelial cells that dissect the dermis. D2-40 and Prox1 immunostains were positive and Wilms tumor 1 (WT-1) immunostain was negative in all cases.ConclusionBenign lymphangioendothelioma represents a lymphatic vascular proliferation. A lack of expression of WT-1 suggests it represents a lymphatic vascular malformation.