Viral Detection in Hydrops Fetalis, Spontaneous Abortion, and Unexplained Fetal Death In Utero
Viral Detection in Hydrops Fetalis, Spontaneous Abortion, and Unexplained Fetal Death In Utero
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DOI：
10.1002/jmv.22007
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发表时间：
2011-04-01
影响因子：
12.7
通讯作者：
Cooper, Robert J.
中科院分区：
文献类型：
--
作者：
Al-Buhtori, Marwan;Moore, Lynette;Cooper, Robert J.
本研究旨在通过组织学检查来探讨胎儿死亡时病毒感染的发生情况。几种病毒剂的DNA的存在。对73例死胎的心、肾、肝、肺、胎盘组织标本进行检查，并与27例择期终止妊娠作对照。从这些样本中提取的DNA被检测是否存在HSV、CMV、EBV、VZV、HHV-6、HHV-7和PVB19。其中巨细胞病毒20例，单纯疱疹病毒5例，细小病毒B19 5例，HHV-7 3例，HHV-6 2例，其中巨细胞病毒20例，单纯疱疹病毒5例。到目前为止，还没有研究报告在结局正常或不利的胎儿组织中检测到HHV-7。在所有终止妊娠的样本中均未发现病毒DNA。在阳性病例中，有8例有双重感染。另有一例对HSV、CMV和HHV-7三种病毒呈阳性。其中2例为HHV-6，1例为HHV-7，3例为PVB19，10例为CMV。在12%的病例中发现多种病毒DNA，提示胎儿丢失病例涉及复杂的危险因素。虽然胎儿死亡的原因通常包括其他因素(例如，染色体异常)，但这些数据表明，病毒感染性病因的发生率可能比以前认为的更高。然而，要建立这种联系，还需要进行更大规模的研究。J.Med.维罗尔。83：679-684,2011。(C)2011年Wiley-Liss，Inc.
This study was undertaken to investigate the occurrence of viral infection in fetal death by examining tissues for. the presence of DNA of several viral agents. Tissue specimens including heart, kidney, liver, lung, and placenta of 73 cases of fetal death were examined with 27 cases of elective termination of pregnancy as a control group. DNA extracted from these samples was tested for the presence of HSV, CMV, EBV, VZV, HHV-6, HHV-7, and PVB19. Viral DNA was found in one or more tissue samples from 25/73 cases (34%): CMV in 20, HSV in 5, parvovirus B19 in 5, HHV-7 in 3, and HHV-6 in 2. The presence of HHV-6 in fetal tissue has been reported rarely. No study so far has reported the detection of HHV-7 in fetal tissues with normal or adverse outcomes. Viral DNA was not found in any of the termination of pregnancy samples. Among the positive cases, eight had dual infection. One further case was positive for three viruses: HSV, CMV, and HHV-7. HHV-6 was the sole infectious agent in two cases, HHV-7 in one case, PVB19 in three, and CMV in ten cases. The finding of multiple viral DNA in 12% of the cases suggests the involvement of complex risk factors in cases of fetal loss. Although the cause of fetal death often includes other factors (e.g., chromosomal abnormalities) these data suggest the incidence of viral infective etiology may be higher than considered previously. However, larger studies are required to establish this link. J. Med. Virol. 83:679-684, 2011. (C) 2011 Wiley-Liss, Inc.