Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice
Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice
复制标题
褪黑素可改善老年小鼠七氟烷麻醉下手术引起的睡眠障碍
DOI：
10.1111/bcpt.13498
复制
发表时间：
2020-10-16
影响因子：
3.1
通讯作者：
Guo, Xiangyang
中科院分区：
文献类型：
--
作者：
Jia, Xixi;Zhang, Liqun;Guo, Xiangyang
手术后睡眠障碍对患者尤其是老年人造成不良影响，这可能与手术和吸入麻醉剂有关。褪黑激素是睡眠-觉醒周期的神经内分泌调节剂。在这项研究中，我们分析了老年褪黑激素缺乏（C57 BL/6 J）小鼠手术后睡眠的变化，并研究了外源性褪黑激素是否可以促进七氟醚麻醉下剖腹手术后的昼夜节律的夹带。结果表明，七氟醚麻醉下的剖腹手术对术后睡眠的影响大于单用七氟醚。麻醉下剖腹手术导致昼夜节律前移，改变了EEG功率密度和NREM睡眠δ功率，延长了REM和NREM睡眠潜伏期。在光照阶段，清醒发作次数趋于减少，清醒发作持续时间升高。然而，这些指标在黑暗阶段呈现相反的趋势。褪黑激素对改善睡眠障碍和恢复生理睡眠有显著疗效，且褪黑激素的大部分有益作用可被褪黑激素受体拮抗剂Luzindole所拮抗。
Post-operative sleep disorders induce adverse effects on patients, especially the elderly, which may be associated with surgery and inhalational anaesthetics. Melatonin is a neuroendocrine regulator of the sleep-wake cycle. In this study, we analysed the alterations of post-operative sleep in aged melatonin-deficient (C57BL/6J) mice, and investigated if exogenous melatonin could facilitate entrainment of circadian rhythm after laparotomy under sevoflurane anaesthesia. The results showed that laparotomy under sevoflurane anaesthesia had a greater influence on post-operative sleep than sevoflurane alone. Laparotomy under anaesthesia led to circadian rhythm shifting forward, altered EEG power density and delta power of NREM sleep, and lengthened REM and NREM sleep latencies. In the light phase, the number of waking episodes tended to decline, and wake episode duration elevated. However, these indicators presented the opposite tendency during the dark phase. Melatonin showed significant efficacy for ameliorating the sleep disorder and restoring physiological sleep, and most of the beneficial effect of melatonin was antagonized by luzindole, a melatonin receptor antagonist.