Gastrointestinal Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia: Risk Factors and Endoscopic Findings
Gastrointestinal Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia: Risk Factors and Endoscopic Findings
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DOI：
10.3390/jcm9010082
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发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Riera-Mestre, Antoni
中科院分区：
文献类型：
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作者：
Maria Mora-Lujan, Jose;Iriarte, Adriana;Riera-Mestre, Antoni
背景资料：我们的目的是描述遗传性出血性毛细血管扩张症（HHT）患者胃肠道出血的危险因素和内镜检查结果。方法：这是一项来自转诊HHT单位的前瞻性研究。当怀疑胃肠道出血时进行内镜检查，患者分为以下几类：有、无和未怀疑的胃肠道受累。结果：67例（27.9%）患者，28例（11.7%）患者没有和145例（60.4%）患者未怀疑胃肠道受累。年龄、吸烟、内皮糖蛋白（ENG）突变和血红蛋白与胃肠道受累相关。毛细血管扩张主要发生在胃和十二指肠，但18.5%的正常食管胃镜（EGD）患者在视频胶囊内镜（VCE）检查中累及GI。毛细血管扩张酶
Background: We aimed to describe risk factors for gastrointestinal (GI) bleeding and endoscopic findings in patients with hereditary hemorrhagic telangiectasia (HHT). Methods: This is a prospective study from a referral HHT unit. Endoscopic tests were performed when there was suspicion of GI bleeding, and patients were divided as follows: with, without, and with unsuspected GI involvement. Results: 67 (27.9%) patients with, 28 (11.7%) patients without, and 145 (60.4%) with unsuspected GI involvement were included. Age, tobacco use, endoglin (ENG) mutation, and hemoglobin were associated with GI involvement. Telangiectases were mostly in the stomach and duodenum, but 18.5% of patients with normal esophagogastroduodenoscopy (EGD) had GI involvement in video capsule endoscopy (VCE). Telangiectases