RETINAL SENSITIVITY AFTER INTRAVITREAL INJECTION OF BEVACIZUMAB FOR THE TREATMENT OF MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION
RETINAL SENSITIVITY AFTER INTRAVITREAL INJECTION OF BEVACIZUMAB FOR THE TREATMENT OF MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION
复制标题
DOI：
10.1097/iae.0b013e31819d4fbf
复制
发表时间：
2009-06-01
影响因子：
3.3
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Yamaike, Noritatsu;Tsujikawa, Akitaka;Yoshimura, Nagahisa
目的：评价贝伐单抗玻璃体内注射治疗视网膜静脉闭塞性黄斑水肿后黄斑功能的改变。方法：对20例黄斑水肿合并视网膜静脉阻塞患者的20只眼进行玻璃体内注射贝伐单抗治疗。在治疗前、治疗后1、3、6个月分别用Micro Perimeter 1对黄斑区进行显微视野检查。结果：治疗后立即发现黄斑功能改善，且持续至少6个月。通过Micro Perimeter 1测量，中央10度视场内的平均视网膜灵敏度（基线时4.9 +/- 2.7 dB）在1个月时提高到7.2 +/- 3.1 dB，在3个月时提高到7.6 +/- 3.4 dB，在6个月时提高到7.7 +/- 3.9 dB （P < 0.001）。在这20只眼睛中，有14只（70%）出现黄斑水肿复发，但通过光学相干断层扫描，在3个月至6个月时，有15只（75%）的眼睛检测到中央凹光感受器外侧影的完整性。结论：在黄斑水肿合并视网膜静脉阻塞的眼睛中，玻璃体内注射贝伐单抗后立即发现黄斑功能改善，并持续至少6个月。视网膜29:757-767,2009
Purpose: To evaluate the change in macular function after intravitreal injection of bevacizumab for the treatment of macular edema associated with retinal vein occlusion.Methods: For this interventional case series, 20 eyes of 20 patients with macular edema associated with retinal vein occlusion were treated with an intravitreal injection of bevacizumab. Microperimetry in the macular area was performed with a Micro Perimeter 1 before and at 1, 3, and 6 months after treatment.Results: Improvement in macular function was detected immediately after treatment and lasted for at least 6 months. As measured by the Micro Perimeter 1, mean retinal sensitivities within the central 10 degrees field (4.9 +/- 2.7 dB at baseline) improved to 7.2 +/- 3.1 dB at 1 month, to 7.6 +/- 3.4 dB at 3 months, and to 7.7 +/- 3.9 dB at 6 months (P < 0.001). Of the 20 eyes, a recurrence of macular edema was observed in 14 (70%), but with the use of optical coherence tomography, integrity of the outer aspect of the foveal photoreceptors was detected at 3 months to 6 months in 15 (75%) eyes.Conclusion: In eyes with macular edema associated with retinal vein occlusion, improvement in macular function was detected immediately after intravitreal injection of bevacizumab and lasted for at least 6 months. RETINA 29:757-767, 2009