Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: insights from a modeling study
Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: insights from a modeling study
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DOI：
10.1038/s41598-018-36485-y
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发表时间：
2019-01-24
影响因子：
4.6
通讯作者：
Colizza, Vittoria
中科院分区：
文献类型：
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作者：
Colombi, Davide;Serra-Cobo, Jordi;Colizza, Vittoria
蝙蝠是哺乳动物中最大比例的病毒性人畜共患病的天然宿主，因此了解蝙蝠中病原体持续存在的条件对于降低人类风险至关重要。专注于欧洲蝙蝠Lysavirus亚型1（EBLV-1），引起狂犬病，我们开发了一个数据驱动的空间显式集合种群模型，调查EBLV-1在加泰罗尼亚的鼠耳蝠和长翼蝠蝙蝠物种的持久性。我们发现，持久性依赖于主机的空间结构，通过迁移性质的M。schreibersii与M.鼠耳蝠，并对受感染动物的存活，随后是暂时免疫。病毒在M.鼠耳蝠我们的研究首次提供了M中EBLV-1进展的流行病学估计。schreibersii。我们的方法可以很容易地适应其他人畜共患病的公共卫生关注的长途迁移和栖息地共享可能发挥重要作用。
Bats are natural reservoirs of the largest proportion of viral zoonoses among mammals, thus understanding the conditions for pathogen persistence in bats is essential to reduce human risk. Focusing on the European Bat Lyssavirus subtype 1 (EBLV-1), causing rabies disease, we develop a data-driven spatially explicit metapopulation model to investigate EBLV-1 persistence in Myotis myotis and Miniopterus schreibersii bat species in Catalonia. We find that persistence relies on host spatial structure through the migratory nature of M. schreibersii, on cross-species mixing with M. myotis, and on survival of infected animals followed by temporary immunity. The virus would not persist in the single colony of M. myotis. Our study provides for the first time epidemiological estimates for EBLV-1 progression in M. schreibersii. Our approach can be readily adapted to other zoonoses of public health concern where long-range migration and habitat sharing may play an important role.