para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis
para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis
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DOI：
10.1021/jacs.9b01908
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发表时间：
2019-04-24
影响因子：
15
通讯作者：
Fernandez-Ibanez, M. Angeles
中科院分区：
文献类型：
--
作者：
Naksomboon, Kananat;Poater, Jordi;Fernandez-Ibanez, M. Angeles
本文报道了苯胺衍生物在Pd/S， o -配体基催化剂上的高度对选择性C-H烯烃反应。该反应在温和的反应条件下进行，反应效率高，底物范围广，包括单、二、三取代的叔、仲、伯胺。S， o配体对底物范围的显著改善和观察到的高准选择性负有责任。该方法操作简单，可扩展，并且可以在有氧条件下进行。
Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under aerobic conditions.