Age-related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius.
Age-related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius.
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DOI：
10.1002/jmri.24641
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发表时间：
2015-04
影响因子：
4.4
通讯作者：
Sinha, Shantanu
中科院分区：
文献类型：
--
作者：
Sinha, Usha;Csapo, Robert;Malis, Vadim;Xue, Yanjie;Sinha, Shantanu
应用弥散张量成像技术（DTI）研究年龄对腓肠肌内外侧肌（MG和LG）弥散张量指数和纤维结构的影响。对5名青年和5名老年受试者进行下肢3T扫描，采用ROI、直方图和基于束的三种方法提取DTI指数。跟踪的纤维被自动编辑，以确保生理相关的轨迹。测量两组肌肉的深层和浅层腱膜的夹角。三种方法的DTI指数测量结果内部一致（相关系数在0.90 ~ 0.99范围内）。MG和LG的第一、第二和第三特征值在老年队列中显著增加（p<0.05），而分数各向异性（FA）随年龄的小幅增加不显著（MG/LG: p=0.39/0.85; 95% CI:[- 0.059/-0.056, 0.116/0.064]）。老年人MG纤维远端纤维长度显著减少（p<0.05）， MG纤维和LG纤维的笔角随年龄的增长而减小，但不显著。纤维萎缩和纤维化增加对弥散指标有相反的影响，与衰老有复杂的依赖关系。纤维结构的变化可能在决定衰老的肌肉功能中起作用。
To investigate age related changes in diffusion tensor indices and fiber architecture of the medial and lateral gastrocnemius (MG and LG) muscles using diffusion tensor imaging (DTI). The lower leg of five young and five senior subjects was scanned at 3T and DTI indices extracted using three methods: ROI, histogram and tract based. Tracked fibers were automatically edited to ensure physiologically relevant tracks. Pennation angles were measured with respect to the deep and superficial aponeuroses of both muscles. The three methods provided internally consistent measures of the DTI indices (correlation coefficient in the range of 0.90-0.99). The primary, secondary and tertiary eigenvalues in the MG and LG increased significantly in the senior cohort (p<0.05), while the small increase in fractional anisotropy (FA) with age was not significant (MG/LG: p=0.39/0.85; 95% CI:[ −0.059/-0.056, 0.116/0.064]). Fiber lengths of MG fibers originating distally were significantly decreased in seniors (p<0.05) while pennation angles decreased with age in the MG and LG but this was not significant. Fiber atrophy and increased fibrosis have opposing effects on the diffusion indices resulting in a complicated dependence with aging. Fiber architectural changes could play a role in determining aging muscle function.
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