Performance of Malaria Rapid Diagnostic Tests as Part of Routine Malaria Case Management in Kenya
Performance of Malaria Rapid Diagnostic Tests as Part of Routine Malaria Case Management in Kenya
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DOI：
10.4269/ajtmh.2009.80.470
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发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Hamel, Mary
中科院分区：
文献类型：
--
作者：
de Oliveira, Alexandre Macedo;Skarbinski, Jacek;Hamel, Mary
Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited. We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case management of patients >= 5 years of age in Kenya. Expert microscopy was used as our gold standard. A total of 1,827 patients were enrolled; 191 (11.6%) were parasitemic by expert microscopy. Sensitivity and specificity of RDTs performed by study staff were 86.6% (95% confidence interval [CI]: 79.8-93.5%) and 95.4% (95% CI: 93.9-96.9%), respectively. Among tests performed by HF staff, RDTs were 91.7% (95% CI: 80.8-100.0%) sensitive and 96.7% (95% CI: 92.8-100.0%) specific, whereas microscopy was 52.5% (95% CI: 33.2-71.9%) sensitive and 77.0% (95% CI: 67.9-86.2%) specific. Our findings suggest that RDTs perform better than microscopy under routine conditions. Further efforts are needed to maintain this high RDT performance over time.
