Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth
Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth
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DOI：
10.1016/j.jri.2015.02.006
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发表时间：
2015-06-01
影响因子：
3.4
通讯作者：
Fatusic, Jasenko
中科院分区：
文献类型：
--
作者：
Hudic, Igor;Stray-Pedersen, Babill;Fatusic, Jasenko
本研究的目的是分析母体血清中孕激素诱导的阻断因子（PIBF）浓度对早产的预测和采样时间间隔的影响。对37名有早产危险的妇女和41名怀孕24至28周的健康孕妇进行了一项前瞻性研究。在37名先兆早产患者中，有11人早产，并形成了三组患者：早产组、先兆早产患者和健康孕妇。在分娩前5天内采集的样本中（6/11,54.5%），PIBF浓度显著低于分娩前5天以上采集的样本（5/11,45.5%；采样至分娩开始的平均间隔为4.1 +/- 1.8天）。对每个观察到的早产参数的个体贡献的多元回归分析表明，缺乏PIBF对早产有显著贡献（p = 0.002）。采用受试者工作特征（ROC）分析评估PIBF对有早产症状的妇女进行早产预测的诊断准确性。PIBF在预测早产方面具有很好的诊断价值，ROC曲线下面积（AUC）为0.956 （95% CI = 0.884-0.989; p < 0.0001）。我们的数据表明，分娩前5天内低于正常妊娠PIBF值可以预测妊娠终止，并有助于早产的诊断。2015爱思唯尔爱尔兰有限公司版权所有。
The objective of this study was to analyze the maternal serum concentration of progesterone-induced blocking factor (PIBF) with regard to the prediction and the interval between sampling and the onset of preterm birth. A prospective study was conducted on a sample of 37 women with threatened pre-term birth and 41 healthy pregnant women between the 24th and 28th gestational weeks. Out of 37 patients with threatened preterm birth 11 delivered pre-term and three groups of patients were formed: the preterm delivery group, patients with threatened preterm delivery, and healthy pregnant women. In samples that were taken within 5 days before labor started (6/11,54.5%), PIBF concentrations were significantly lower than in those obtained more than 5 days before labor (5/11, 45.5%; the mean interval between sampling and the onset of labor was 4.1 +/- 1.8 days). Multiple regression analysis of the individual contributions of each observed parameter for preterm delivery demonstrated the significant contribution of a lack of PIBF to preterm birth (p = 0.002). Receiver operating characteristics (ROC) analysis was performed to evaluate the diagnostic accuracy of PIBF for the prediction of preterm birth of women with symptoms of pre-term delivery. The PIBF demonstrated an excellent diagnostic value in the prediction of preterm birth with an area under the ROC curve (AUC) of 0.956 (95% CI = 0.884-0.989; p < 0.0001). Our data suggest that pregnancy termination can be predicted by lower than normal pregnancy PIBF values within 5 days before labor and can contribute to the diagnosis of preterm birth. (C) 2015 Elsevier Ireland Ltd. All rights reserved.