INCIDENCE AND PREVALENCE OF TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN ICELANDIC CHILDREN 1970-1989
INCIDENCE AND PREVALENCE OF TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN ICELANDIC CHILDREN 1970-1989
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DOI：
10.1007/bf00399936
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发表时间：
1992-09-01
期刊：
影响因子：
8.2
通讯作者：
THORSSON, AV
中科院分区：
文献类型：
--
作者：
HELGASON, T;DANIELSEN, R;THORSSON, AV
通过使用初级和二级数据源进行登记和验证，已完全确定了1970-1989年冰岛0-14岁儿童1型（胰岛素依赖型）糖尿病的发病率和流行率。20年期间，年龄调整后的平均年发病率为每10万人9.4（95%置信区间7.8-11.3）;男孩（9.9; 7.7-12.7）和女孩（8.8; 6.7-11.5）相似。1970-1979年的发病率为8.0（6.0-10.6），1980-1989年的发病率相当，为10.8（8.4-13.8）（p > 0.10）。通过Poisson回归分析，发病率的变化与诊断时的年龄有关（p < 0.001），而诊断时日历年的线性趋势未达到统计学显著性（p = 0.07）。然而，二次曲线更好地描述了发病率的时间变化（p < 0.05）。到1979年底和1989年底，每千人的总患病率相似，分别为0.45（0.30-0.65）和0.57（0.40-0.79）。总之，这项研究证实，与其他北欧国家相比，冰岛儿童1型糖尿病的发病率和患病率都很低。这些发现可能表明，与纬度或环境温度无关的环境因素起着致病作用。
Through use of primary and secondary data sources for registration and validation, the incidence and prevalence of Type 1 (insulin-dependent) diabetes mellitus in children aged 0-14 years in Iceland has been-completely ascertained for the years 1970-1989. The age-adjusted mean annual incidence per 100,000 for the 20-year period was 9.4 (95% confidence interval 7.8-11.3); similar for boys (9.9; 7.7-12.7) and girls (8.8; 6.7-11.5). Between 1970-1979 the incidence was 8.0 (6.0-10.6) and between 1980-1989 it was comparable-at 10.8 (8.4-13.8) (p > 0.10). By Poisson regression analysis the variation in incidence was related to age at diagnosis (p < 0.001), while a linear trend for calendar year at diagnosis did not reach statistical significance (p = 0.07). A quadratic curve, however, better described the temporal variation in incidence (p < 0.05). The total prevalence per 1,000 by the end of 1979 and 1989 was similar, 0.45 (0.30-0.65) an d 0.57 (0.40-0.79), respectively. In conclusion, this study confirms that both the incidence and prevalence of childhood Type 1 diabetes in Iceland are low compared to the other Nordic countries. The findings may suggest a causative role for environmental factors that are not related to latitude or ambient temperature.