Vitiligo: interplay between oxidative stress and immune system
Vitiligo: interplay between oxidative stress and immune system
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DOI：
10.1111/exd.12103
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发表时间：
2013-04-01
影响因子：
3.6
通讯作者：
Begum, Rasheedunnisa
中科院分区：
文献类型：
--
作者：
Laddha, Naresh C.;Dwivedi, Mitesh;Begum, Rasheedunnisa
白癜风是一种多因素多基因疾病，发病机制复杂，与遗传和非遗传因素有关。白癜风发病机制的确切操作方式仍然难以捉摸。关于黑素细胞损失的理论是基于自身免疫、细胞毒性、氧化-抗氧化和神经机制。活性氧（ROS）过量已被记录在活动性白癜风皮肤。除了酪氨酸酶之外，许多蛋白质也受到影响。这可能是氧化应激是白癜风的主要原因之一。然而，也有充分的证据表明白癜风的免疫过程发生了改变，特别是在慢性和进行性疾病中。免疫系统的先天性和适应性武器似乎参与作为一个主要的事件或作为一个次要的促进后果。在白癜风的发病机制中，有关于ROS和免疫系统之间的相互作用的推测。本文重点介绍了将氧化应激和免疫系统与白癜风发病机制联系起来的科学证据，从而证明氧化应激-自身免疫介导的黑素细胞丢失是一个会聚的终末途径。
Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis, linked with both genetic and non-genetic factors. The precise modus operandi for vitiligo pathogenesis has remained elusive. Theories regarding loss of melanocytes are based on autoimmune, cytotoxic, oxidant-antioxidant and neural mechanisms. Reactive oxygen species (ROS) in excess have been documented in active vitiligo skin. Numerous proteins in addition to tyrosinase are affected. It is possible that oxidative stress is one among the main principal causes of vitiligo. However, there also exists ample evidence for altered immunological processes in vitiligo, particularly in chronic and progressive conditions. Both innate and adaptive arms of the immune system appear to be involved as a primary event or as a secondary promotive consequence. There is speculation on the interplay, if any, between ROS and the immune system in the pathogenesis of vitiligo. The article focuses on the scientific evidences linking oxidative stress and immune system to vitiligo pathogenesis giving credence to a convergent terminal pathway of oxidative stress-autoimmunity-mediated melanocyte loss.