Tooth loss, dementia and neuropathology in the Nun study
Tooth loss, dementia and neuropathology in the Nun study
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DOI：
10.14219/jada.archive.2007.0046
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发表时间：
2007-10-01
影响因子：
3.9
通讯作者：
Kryscio, Richard J.
中科院分区：
文献类型：
--
作者：
Stein, Pamela Sparks;Desrosiers, Mark;Kryscio, Richard J.
背景。许多研究已经将痴呆症与随后的口腔健康恶化联系起来。然而，很少有研究者将口腔疾病作为痴呆发展的潜在风险因素进行研究。作者进行了一项研究，以调查口腔疾病史与痴呆发展之间的潜在联系。纵向牙科记录补充了从修女研究中收集的144名密尔沃基参与者的10年认知评估数据，这是一项关于衰老和阿尔茨海默病的纵向研究，年龄在75至98岁之间。对118名死亡的参与者的尸检结果进行了神经病理学检查。牙齿数量少，痴呆患病率高，发病率高。牙齿最少的参与者患痴呆症的风险和发病率最高。临床意义。缺牙症或很少（1到9颗）牙齿可能是晚年痴呆的前兆。
Background. Numerous studies have linked dementia to the subsequent deterioration of oral health. Few investigators, however, have examined oral disease as a potential risk factor in the development of dementia. The authors conducted a study to investigate a potential association between a history of oral disease and the development of dementia.Methods. Longitudinal dental records supplemented data collected from 10 annual cognitive assessments of 144 Milwaukee participants in the Nun Study, a longitudinal study of aging and Alzheimer disease, who were 75 to 98 years old. Neuropathologic findings at autopsy were available for 118 participants who died.Results. A low number of teeth increased the risk of higher prevalence and incidence of dementia.Conclusion. Participants with the fewest teeth had the highest risk of prevalence and incidence of dementia.Clinical Implications. Edentulism or very few (one to nine) teeth may be predictors of dementia late in life.