Identification of new allelic variants in the ovine prion protein (PrP) gene
Identification of new allelic variants in the ovine prion protein (PrP) gene
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DOI：
10.1046/j.1439-0388.2002.00335.x
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发表时间：
2002-08-01
影响因子：
2.6
通讯作者：
Brenig, B
中科院分区：
文献类型：
--
作者：
Kutzer, T;Pfeiffer, I;Brenig, B
在33个不同品种的1108只德国绵羊中研究了羊瘙痒病与朊蛋白（PrP）基因多态性的关系。研究的目的是确定PrP基因的密码子136、154和171，这些密码子对羊瘙痒病易感性很重要。（AHR和VRR）在Texel品种中发现，不同品种间PrP基因型频率的比较显示出明显的差异。品种，如Texel表现出复杂的基因型分布超过17个变种，而品种，如弗里斯兰奶羊只表示7种不同的基因型。
The association between scrapie and polymorphisms of the prion protein (PrP) gene was studied in 1108 German sheep of 33 different breeds. The aim of the investigation was the determination of the codons 136, 154 and 171 of the PrP gene, which are important for scrapie susceptibility.In addition to the published allelic variants ARR, ARQ, AHQ, ARH and VRQ, two novel, rare haplotypes (AHR and VRR) were found in the breeds of Texel, Nolana and Suffolk.A comparison of PrP genotype frequencies among the analysed different breeds revealed distinct variations. Breeds such as Texel showed a complex genotype distribution over 17 variants, while breeds such as Friesian Milk Sheep indicated only seven different genotypes.