Relationship between blood flow and steroidogenesis in the rabbit corpus luteum.
Relationship between blood flow and steroidogenesis in the rabbit corpus luteum.
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DOI：
10.1530/jrf.0.0840513
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发表时间：
1988-11
期刊：
影响因子：
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通讯作者：
M. C. Wiltbank;R. Dysko;K. P. Gallagher;P. Keyes
中科院分区：
文献类型：
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作者：
M. C. Wiltbank;R. Dysko;K. P. Gallagher;P. Keyes
在盐水处理前、处理后 1 小时和 3 小时（N = 8）或用氨鲁米特抑制孕酮合成后（N = 10），用示踪剂标记的微球测量假孕兔黄体中的血流量。治疗前黄体血流量（29.5 +/- 3.9 ml/min.g-1（平均值+/- s.e.m.）远高于其他组织的血流量（卵巢基质= 2.9 +/- 0.6；子宫= 0.5 +/- 0.1；肾上腺= 2.6 +/- 0.2 ml/min.g-1）。氨鲁米特降低血清孕酮1 小时内减少 60%，但黄体血流量没有变化（26.2 +/- 3.5 ml/min.g-1），服用氨鲁米特后 3 小时，血清孕酮仍然较低，黄体血流量轻微降低至 22.5 +/- 3.4 ml/min.g-1。这种降低与平均动脉血压显着下降有关，导致黄体血管阻力不受氨鲁米特影响。对这些数据的进一步分析表明，血清孕酮浓度与黄体血流量或其他组织血流量没有显着相关性，相反，平均动脉血压与黄体血流量高度相关（r = 0.80；P 小于 0.001），但与卵巢基质血流量（r = 0.04）或肾上腺血流量（r = 0.06）无关。黄体血流量对黄体孕酮产生的变化并不敏感，这表明黄体血流量随着动脉血压的变化而被动变化。
Blood flow in the corpus luteum of the pseudopregnant rabbit was measured with tracer-labelled microspheres before and at 1 and 3 h after saline treatment (N = 8) or after inhibition of progesterone synthesis with aminoglutethimide (N = 10). Before treatment luteal blood flow (29.5 +/- 3.9 ml/min.g-1 (mean +/- s.e.m.] was much higher than blood flow to other tissues (ovarian stroma = 2.9 +/- 0.6; uterus = 0.5 +/- 0.1; adrenal gland = 2.6 +/- 0.2 ml/min.g-1). Aminoglutethimide reduced serum progesterone by 60% within 1 h but luteal blood flow was unchanged (26.2 +/- 3.5 ml/min.g-1). At 3 h after aminoglutethimide, serum progesterone remained low and luteal blood flow was slightly reduced to 22.5 +/- 3.4 ml/min.g-1. This reduction was associated with a significant decline in mean arterial blood pressure which resulted in luteal vascular resistance being unaltered by aminoglutethimide treatment. Further analysis of these data indicated that serum progesterone concentration was not significantly correlated with blood flow to the corpora lutea or with blood flow to other tissues. In contrast, mean arterial blood pressure was highly correlated with blood flow to the corpus luteum (r = 0.80; P less than 0.001) but not to the ovarian stroma (r = 0.04), or adrenal gland (r = 0.06). These results indicate that luteal blood flow is not acutely responsive to changes in luteal progesterone production and suggest that luteal blood flow changes passively with changes in arterial blood pressure.