LRRK2 at the interface of autophagosomes, endosomes and lysosomes.
LRRK2 at the interface of autophagosomes, endosomes and lysosomes.
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DOI：
10.1186/s13024-016-0140-1
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发表时间：
2016-12-07
影响因子：
15.1
通讯作者：
Cookson MR
中科院分区：
文献类型：
--
作者：
Roosen DA;Cookson MR
Over the past 20 years, substantial progress has been made in identifying the underlying genetics of Parkinson’s disease (PD). Of the known genes, LRRK2 is a major genetic contributor to PD. However, the exact function of LRRK2 remains to be elucidated. In this review, we discuss how familial forms of PD have led us to hypothesize that alterations in endomembrane trafficking play a role in the pathobiology of PD. We will discuss the major observations that have been made to elucidate the role of LRRK2 in particular, including LRRK2 animal models and high-throughput proteomics approaches. Taken together, these studies strongly support a role of LRRK2 in vesicular dynamics. We also propose that targeting these pathways may not only be beneficial for developing therapeutics for LRRK2-driven PD, but also for other familial and sporadic cases.
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影响因子：
11.2
作者：
Biskup, Saskia;Moore, Darren J.;Dawson, Valina L.
通讯作者：
Dawson, Valina L.
DOI：
10.1073/pnas.1318306111
发表时间：
2014-02-18
影响因子：
11.1
作者：
Beilina, Alexandria;Rudenko, Iakov N.;Cookson, Mark R.
通讯作者：
Cookson, Mark R.
影响因子：
11.4
作者：
Cho, Hyun Jin;Yu, Jia;Cai, Huaibin
通讯作者：
Cai, Huaibin
大鼠富含亮氨酸重复激酶 2 (LRRK2) 的缺失会导致外周器官逐渐出现异常表型。
影响因子：
3.7
作者：
Baptista MA;Dave KD;Frasier MA;Sherer TB;Greeley M;Beck MJ;Varsho JS;Parker GA;Moore C;Churchill MJ;Meshul CK;Fiske BK
通讯作者：
Fiske BK
影响因子：
11.2
作者：
Funayama, M;Hasegawa, K;Obata, F
通讯作者：
Obata, F