The effect of visually evoked innate fear on reward-associated conditional response and reversal learning in mice
The effect of visually evoked innate fear on reward-associated conditional response and reversal learning in mice
复制标题
视觉诱发的先天恐惧对小鼠奖励相关条件反应和逆转学习的影响
DOI：
10.1016/j.physbeh.2021.113648
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发表时间：
2021
影响因子：
2.9
通讯作者：
Jin Li
中科院分区：
文献类型：
--
作者：
Jing;Shuo Li;Bingyang Wang;N. Wu;Fei Li;Jin Li
对视觉引起的先天恐惧的反应对于生存至关重要，并影响动物对环境威胁的认知和行为。然而，之前的研究报告了恐惧与执行行为相互作用的矛盾结果。为了解决这个问题，本研究调查了迫在眉睫的刺激驱动的视觉先天恐惧对对蔗糖的低或高动机的小鼠的奖励相关条件反应和逆转学习的影响。暴露于迫近刺激的低动机小鼠在固定比率 1 计划中的条件反应测试中表现出效率降低，并且在渐进比率强化计划中测试执行动机受损。然而，受到迫在眉睫的刺激的高积极性小鼠表现出不受影响的条件反应，但执行动机增加。在逆转学习程序中，中期迫在眉睫的刺激导致低动机和高动机小鼠的认知灵活性缺陷。因此，这些结果阐明了视觉诱发的先天恐惧对条件反应和逆转学习的影响，并进一步表明这些影响与内部动机和外部恐惧刺激有关。
The response to visually evoked innate fear is essential for survival and impacts the cognition and behavior of animals to threats in the environment. However, contradictory findings of the interaction of fear and executive behaviors were reported by previous studies. To address this question, the present study investigated the effect of looming stimuli-driven visually innate fear on reward-associated conditioned response and reversal learning in mice with low or high motivation for sucrose. The mice with low motivation exposed to looming stimuli displayed reduced efficiency in the test of conditional response in the fixed ratio 1 schedule and impaired executive motivation as tested in the progressive ratio schedule of reinforcement. However, the high motivated mice exposed to looming stimuli showed an unaffected conditional response but an increased executive motivation. In the reversal learning program, looming stimuli at the middle stage caused deficits in cognitive flexibility in the mice with low and high motivation. Therefore, these results illuminate the impact of visually evoked innate fear on conditional response and reversal learning and further show that the impacts are relevant to internal motivation and external fear stimuli.
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影响因子：
3.7
作者：
Small, DM;Gitelman, D;Mesulam, MM
通讯作者：
Mesulam, MM
影响因子：
3.7
作者：
Mohanty, Aprajita;Gitelman, Darren R.;Mesulam, M. Marsel
通讯作者：
Mesulam, M. Marsel
影响因子：
19.9
作者：
Pessoa, Luiz
通讯作者：
Pessoa, Luiz
影响因子：
5.4
作者：
Peciña S;Schulkin J;Berridge KC
通讯作者：
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