[Expression of MicroRNA-148/152 Family in the Hematological Malignancies].
[Expression of MicroRNA-148/152 Family in the Hematological Malignancies].
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DOI：
10.7534/j.issn.1009-2137.2015.04.052
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发表时间：
2015-08-01
期刊：
影响因子：
--
通讯作者：
Li, Yan
中科院分区：
文献类型：
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作者：
Wang, Xiao-Xue;Wang, Yue;Li, Yan
MicroRNA (miRNA) 是含有 18-22 个核苷酸的小型非编码 RNA 分子，通过与靶基因 3'-非翻译区 (3'-UTR) 中的序列不完美的相互作用来调节基因表达。 microRNA-148/152 (miR-148/152)家族成员包括microRNA-148a (miR-148a)、microRNA-148b (miR-148b)和microRNA-152 (miR-152)，在一些肿瘤疾病的发生发展中具有重要意义。多项研究表明，miR-148/152家族成员在多种恶性肿瘤中存在不同表达，发挥多种生物学功能，如通过调节靶基因的表达来调节肿瘤生长、增殖、凋亡、血管生成、药物敏感性等。 miR-148/152 家族受其 CPG 岛甲基化的调节，从而降低 miR-148/152 家族成员的表达。通过靶基因 DNMT1/3b（DNA 甲基化的重要基因）观察到 DNA 甲基化与 miR-148/152 家族成员之间的相互作用。因此 DNMT1/3b 的表达与 miR-148a/152 的表达水平成反比。这可能导致 DNMT1/3b 过度表达，促进 DNA 甲基化。然后，可以表达更多的DNMT1/3b。肿瘤中可能存在一种新的 miR-148a/152-DNMT1/3b 调节回路。表观遗传异常，特别是启动子的高甲基化在血液系统恶性肿瘤的发生、发展中发挥着重要作用。去甲基化治疗已成为另一种重要的治疗方式。本文综述了miR-148/152家族在血液肿瘤中的表达情况，旨在阐明DNA甲基化修饰与microRNA之间关系的意义。
MicroRNAs (miRNAs) are small noncoding RNA molecules containing 18-22 nucleotides that regulate gene expression through imperfect interactions with sequences in the 3'-untranslated region (3'-UTR) of target genes. Members of the microRNA-148/152 (miR-148/152) family, which include microRNA-148a (miR-148a), microRNA-148b (miR-148b) and microRNA-152 (miR-152), are of great importance in the development of some tumor diseases. Several studies have demonstrated that members of the miR-148/152 family were expressed differently in many kinds of malignancies, and they play a variety of biological functions, such as regulating tumor growth, proliferation, apoptosis, angiogenesis, and sensitivity to drugs through regulating the expression of target genes. The miR-148/152 family is regulated by methylation of their CPG islands, which reduce the expression of miR-148/152 family members. Interaction has been observed between DNA methylation and miR-148/152 family members through their target gene: DNMT1/3b, an important gene for DNA methylation. So expressions of DNMT1/3b are inversely restricted to the expression level of miR-148a/152. This might result in overexpression of DNMT1/3b, promoting DNA methylation. And then, more DNMT1/3b can be expressed. A novel miR-148a/152-DNMT1/3b regulatory circuit might exist in tumors. Epigenetic abnormalities, especially high methylation of promoter play an important role in occurrence and development of hematological malignancies. Demethylation treatment has become another important way for the treatment. This article summarizes the expression of miR-148/152 family in hematological malignancies, aiming at expounding the signicance of relationship between DNA methylation modification and microRNA.