Nonrandom variability of respiration during sleep in healthy humans
Nonrandom variability of respiration during sleep in healthy humans
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DOI：
10.1093/sleep/28.4.411
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发表时间：
2005-04-01
期刊：
影响因子：
5.6
通讯作者：
Jerrentrup, A
中科院分区：
文献类型：
--
作者：
Rostig, S;Kantelhardt, JW;Jerrentrup, A
研究目标：呼吸之间的变异性并不是纯粹随机的，而是以短期和长期尺度上的相关性为特征。短期相关性可能反映了完整的代谢控制机制。为了调查与非快速眼动 (NREM) 睡眠相比，快速眼动 (REM) 期间呼吸的较高变异性是否具有随机或非随机性质（反映呼吸控制的改变），确定了呼吸驱动和计时的短期和长期相关性。设计：使用连接到全面罩的呼吸速度描记器进行整夜多导睡眠图。对于 NREM 和 REM 睡眠期间的每次呼吸，根据定量气流对呼吸成分进行分析。设置：数据收集在睡眠实验室进行。参与者：29 名健康受试者（年龄，25.8 +/- 3.1 岁）。测量和结果：NREM 睡眠期间的呼吸计时和驱动成分实际上不存在长期相关性，而在 REM 睡眠期间则存在。 NREM 和 REM 睡眠期间的呼吸动力、潮气量和每分钟通气量均存在短期相关性。在所有时间成分中，不存在额外的短期相关性。 结论：我们得出的结论是，从 NREM 睡眠到 REM 睡眠，呼吸驱动的短期调节仍然受到代谢控制，并且明显不同于节律生成功能的短期调节。快速眼动睡眠期间呼吸计时和驱动力的调节具有额外的长期相关性。我们推测这是阶段性快速眼动睡眠期间皮质影响的结果。因此，快速眼动睡眠期间呼吸的变化包含非随机成分，因此即使各成分之间存在很大的时间滞后，呼吸成分仍然相互依赖。
Study objectives: Breath-to-breath variability is not purely random but is, instead, characterized by correlations on short- and long-term scales. Shortterm correlations might reflect intact metabolic-control mechanisms. To investigate whether the higher variability of breathing during rapid eye movement (REM) compared to non-REM (NREM) sleep is of random or nonrandom nature-reflecting an altered respiratory control-short-term and long-term correlations of respiratory drive and timing were determined. Design: A full-night polysomnogram with a pneumotachograph attached to a full-face mask was performed. For each breath during NREM and REM sleep, respiratory components were analyzed based on the quantitative airflow.Setting: Data collection took place in the sleep laboratory.Participants: Twenty-nine healthy subjects (age, 25.8 +/- 3.1 years).Measurements and Results: Long-term correlations are practically absent in respiratory timing and drive components during NREM sleep, whereas they are present during REM sleep. Short-term correlations are present in respiratory drive, tidal volume, and minute ventilation during both NREM and REM sleep. In all timing components, additional short-term correlations are absent.Conclusion: We conclude that from NREM to REM sleep, short-term regulation of respiratory drive remains strongly metabolically controlled and clearly different from the short-term regulation of the rhythm-generating function. Regulation of respiratory timing and drive during REM sleep is characterized by additional long-term correlations. We speculate that this is the result of cortical influences during phasic REM sleep. Thus, the variability of breathing during REM sleep contains a nonrandom component, such that breathing components remain dependent upon each other even with large time lags between components.