Inbreeding depression across the lifespan in a wild mammal population
Inbreeding depression across the lifespan in a wild mammal population
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DOI：
10.1073/pnas.1518046113
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发表时间：
2016-03-29
影响因子：
11.1
通讯作者：
Pemberton, Josephine M.
中科院分区：
文献类型：
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作者：
Huisman, Jisca;Kruuk, Loeske E. B.;Pemberton, Josephine M.
近亲繁殖抑制是受威胁物种保护的主要关注点，避免近亲繁殖被认为是交配系统进化的关键驱动力。然而，在自然群体中的个体近亲繁殖系数的估计一直具有挑战性，因此，近亲繁殖对健身的全面影响仍然不清楚。基因组近交系数可以解决长期缺乏成年性状和总适合度的近交衰退数据。在这里，我们调查近交抑郁症的生活史性状和健身的范围内的野生种群的红鹿（马鹿）在苏格兰使用来自密集的单核苷酸多态性（SNP）数据（F-grm）的个人近交系数。我们发现Fgrm和年度繁殖成功率在两性之间的关联，和母亲的近亲繁殖系数和后代的生存。我们也证实了先前的研究结果近亲繁殖抑郁症的出生体重和少年生存。与此相反，近亲繁殖系数计算从一个深，比较完整的系谱检测到近亲繁殖抑郁症的少年生存，但不是在任何成年健身组件。近亲繁殖对终生繁殖成功率（LBS）的总影响是巨大的，在两种性别：F-grm = 0.125，半同胞交配，LBS下降了72%的女性和95%的男性。我们的研究结果表明，基于SNP的近亲繁殖的估计提供了一个强大的工具，用于评估自然种群中的近亲繁殖抑郁症，并建议，到目前为止，成年性状的近亲繁殖抑郁症的患病率可能被低估。
Inbreeding depression is of major concern for the conservation of threatened species, and inbreeding avoidance is thought to be a key driver in the evolution of mating systems. However, the estimation of individual inbreeding coefficients in natural populations has been challenging, and, consequently, the full effect of inbreeding on fitness remains unclear. Genomic inbreeding coefficients may resolve the long-standing paucity of data on inbreeding depression in adult traits and total fitness. Here we investigate inbreeding depression in a range of life history traits and fitness in a wild population of red deer (Cervus elaphus) in Scotland using individual inbreeding coefficients derived from dense Single-Nucleotide Polymorphism (SNP) data (F-grm). We find associations between Fgrm and annual breeding success in both sexes, and between maternal inbreeding coefficient and offspring survival. We also confirm previous findings of inbreeding depression in birth weight and juvenile survival. In contrast, inbreeding coefficients calculated from a deep and comparatively complete pedigree detected inbreeding depression in juvenile survival, but not in any adult fitness component. The total effect of inbreeding on lifetime breeding success (LBS) was substantial in both sexes: for F-grm = 0.125, a value resulting from a half-sib mating, LBS declined by 72% for females and 95% for males. Our results demonstrate that SNP-based estimates of inbreeding provide a powerful tool for evaluating inbreeding depression in natural populations, and suggest that, to date, the prevalence of inbreeding depression in adult traits may have been underestimated.