Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases.
Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases.
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含 SH2 的蛋白酪氨酸磷酸酶对 B 细胞信号转导的调节。
DOI：
10.1006/smim.1998.0125
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发表时间：
1998
影响因子：
7.8
通讯作者：
Neel,BG
中科院分区：
文献类型：
--
作者：
Siminovitch,KA;Neel,BG
酪氨酰磷酸化在B淋巴细胞信号传导中起关键作用。蛋白酪氨酸激酶（PTKs）调节B细胞信号通路的机制已被广泛研究。最近，注意力转向蛋白酪氨酸磷酸酶（PTP），特别是那些含有SH 2结构域。SHP-1已被证明是抗原受体信号传导的关键调节剂，至少部分地通过含有SHP-1结合位点的抑制性共受体起作用。通过对SHP-1基因中携带天然突变的小鼠以及B细胞信号传导途径的其他组分中携带靶向突变的小鼠的分析，这些研究得到了很大的帮助。SHP-2在B细胞中的功能尚不清楚，尽管在其他细胞系统中的研究表明它可能起信号增强作用。
Tyrosyl phosphorylation plays a key role in B lymphocyte signaling. The mechanisms by which protein tyrosine kinases (PTKs) regulate signaling pathways in B cells have been investigated extensively. More recently, attention has turned to the protein–tyrosine phosphatases (PTPs), particularly those containing SH2 domains. SHP-1 has been shown to be a critical regulator of antigen receptor signaling, acting, at least in part, via inhibitory co-receptors containing SHP-1 binding sites. These studies have been aided considerably by the analysis of mice carrying naturally-arising mutations in the SHP-1 gene as well as mice bearing targeted mutations in other components of B cell signaling pathways. The function of SHP-2 in B cells is less clear, although studies in other cell systems suggests that it may play a signal-enhancing role.