EFFECT OF A SINGLE OAT BRAN CEREAL BREAKFAST ON SERUM-CHOLESTEROL, LIPOPROTEINS, AND APOLIPOPROTEINS IN PATIENTS WITH HYPERLIPOPROTEINEMIA TYPE-IIA
EFFECT OF A SINGLE OAT BRAN CEREAL BREAKFAST ON SERUM-CHOLESTEROL, LIPOPROTEINS, AND APOLIPOPROTEINS IN PATIENTS WITH HYPERLIPOPROTEINEMIA TYPE-IIA
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DOI：
10.1177/0148607192016006533
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发表时间：
1992-11-01
影响因子：
3.4
通讯作者：
KASPER, H
中科院分区：
文献类型：
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作者：
BARTRAM, P;GERLACH, S;KASPER, H
在几项研究中，燕麦麸皮强化饮食具有降低血清胆固醇的作用，其中燕麦麸皮每天给予数次。也有报告称日常饮食的伴随变化，即能量摄入减少或饮食中脂肪组成的变化，并用于解释燕麦的降胆固醇作用。本研究的目的是取代只有传统的欧式早餐由一个单一的燕麦麸皮谷物牛奶什锦早餐含有60克燕麦麸皮，并测量这种饮食的修改对血脂的影响，在13例高胆固醇血症Ⅱ a型。与3周基线期相比，摄入燕麦麸的第一、第二和第三周，血清总胆固醇（7.38 +/- 0.35 mmol/L，平均值+/- SEM）分别降低了10.9%、8.4%和9.7%（p <0.01）。高密度脂蛋白和低密度脂蛋白胆固醇以及载脂蛋白A1在燕麦麸期间降低了相同的程度（8至11%; p < .05），而载脂蛋白B100（低密度脂蛋白的主要成分）则明显降低了25.8%（p < .01）。通过基线、燕麦麸和随访期的3天食物记录获得的膳食数据未显示出研究期间之间的任何差异，除了膳食纤维，由于每日燕麦麸摄入量，膳食纤维在测试期间从21.9 g/天增加到42.4 g/天（p <0.002）。根据这些结果，强烈建议用燕麦麸谷物牛奶什锦早餐简单替代传统的欧式早餐，以降低IIa型高脂蛋白血症患者的血清总胆固醇和其他致动脉粥样硬化脂质组分。
Serum cholesterol-lowering effects of oat bran-enriched diets have been indicated in several studies in which oat bran was given several times a day. Concomitant changes in the daily diet, ie, a diminished energy intake or changes in the composition of fats in the diet, also have been reported and used to explain the hypocholesterolemic effect of oats. The present study was designed to replace only the conventional continental breakfast by a single oat bran cereal muesli containing 60 g of oat bran and to measure the effects of this dietetic modification on serum lipids in 13 patients with hypercholesterolemia type IIa. Compared with a 3-week baseline period, total serum cholesterol (7.38 +/- 0.35 mmol/L, mean +/- SEM) was reduced by 10.9, 8.4, and 9.7% in the first, second, and third week of oat bran ingestion (p < .01). High-density lipoprotein and low-density lipoprotein cholesterol as well as apolipoprotein A1 decreased to the same extent (8 to 11%; p < .05) during the oat bran period, whereas a pronounced reduction of 25.8% was seen for apolipoprotein B100 (p < .01), which is a major component of low-density lipoprotein. Dietary data obtained by 3-day food records at baseline, oat bran, and follow-up period did not show any differences between the study periods except for dietary fiber, which was increased from 21.9 g/day to 42.4 g/day (p < .002) during the test period because of the daily oat bran intake. On the basis of these results the simple replacement of a conventional continental breakfast by an oat bran cereal muesli can be highly recommended to lower total serum cholesterol and other atherogenic lipid fractions in patients with hyperlipoproteinemia type IIa.