Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimaging
Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimaging
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DOI：
10.1016/j.neuropsychologia.2004.04.023
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发表时间：
2004-01-01
期刊：
影响因子：
2.6
通讯作者：
Berman, KF
中科院分区：
文献类型：
--
作者：
Gerton, BK;Brown, TT;Berman, KF
数字向前（DF）和向后（DB）任务是广泛使用的神经心理学测量方法，被认为可以利用语音处理和工作记忆的重叠系统。对局灶性脑损伤的研究已经部分阐明了对这些任务至关重要的大脑区域。然而，关于完整大脑中潜在的功能性神经解剖学的信息相对较少。因此，我们在两个正电子发射断层扫描（PET）实验中检查了这些任务的共享和独立神经系统。在实验 1 中，八名健康参与者在测量局部脑血流量 (rCBF) 期间执行言语 DF、DB 和感觉运动控制任务。 DF 和 DB 分别激活额叶、顶叶和小脑区域，并显着激活内侧枕叶皮层。消除可能的视觉空间混淆。实验 2 在另外六名健康参与者身上重复了第一个实验，这些参与者在研究过程中被蒙住眼睛。两个实验组之间没有发现激活差异。两项实验的综合数据表明，DF 和 DB 依赖于与工作记忆相关的很大程度上重叠的功能神经系统，最显着的是右背外侧前额叶皮层 (DLPFC) 和双侧顶下小叶 (IPL) 以及前扣带回（与注意力努力相关的区域）。 DF 中的激活程度随着任务难度的增加而线性增加。 DB还招募了双侧DLPFC、左侧IPL和布罗卡区。内侧枕叶皮层（包括较高和较低的视觉处理区域）在 DF 和 DB 中均被强烈激活，并且不能归因于视觉处理本身，这表明这些听觉-语言任务可能存在视觉意象策略。由爱思唯尔有限公司出版
The digits forward (DF) and backward (DB) tasks are widely used neuropsychological measures believed to tap overlapping systems of phonological processing and working memory. Studies of focal brain lesions have partially elucidated the brain regions essential for these tasks; however relatively little information exists on the underlying functional neuroanatomy in the intact brain. We therefore examined the shared and separate neural systems of these tasks in two positron emission tomography (PET) experiments. In Experiment 1, eight healthy participants performed verbal DF, DB, and a sensorimotor control task during measurement of regional cerebral blood flow (rCBF). DF and DB each activated frontal, parietal, and cerebellar regions as well as prominently activating medial occipital cortex. To eliminate possible visuospatial confounds. Experiment 2 replicated the first experiment in six additional healthy participants who were blindfolded during the study. No differences in activation were found between the two experimental groups. Combined data from both experiments demonstrate that DF and DB rely upon a largely overlapping functional neural system associated with working memory, most notably right dorsolateral prefrontal cortex (DLPFC) and bilateral inferior parietal lobule (IPL) as well as the anterior cingulate, a region associated with attentional effort. The degree of activation increased linearly with increasing task difficulty in DF. DB additionally recruited bilateral DLPFC, left IPL, and Broca's area. Medial occipital cortex (including higher and lower visual processing areas) was robustly activated in both DF and DB and could not be attributed to visual processing per se, suggesting a possible visual imagery strategy for these aural-verbal tasks. Published by Elsevier Ltd.