Prognosis and hormone receptor status in older and younger patients with advanced-stage papillary serous ovarian carcinoma
Prognosis and hormone receptor status in older and younger patients with advanced-stage papillary serous ovarian carcinoma
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DOI：
10.1016/j.ygyno.2009.08.023
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发表时间：
2009-12-01
影响因子：
4.7
通讯作者：
Matulonis, Ursula A.
中科院分区：
文献类型：
--
作者：
Liu, Joyce F.;Hirsch, Michelle S.;Matulonis, Ursula A.
目标。先前的研究表明，年龄较大的卵巢癌患者预后更差。然而，很少有研究研究老年患者肿瘤中不同的蛋白质表达模式是否与较差的预后相关。我们通过构建由III期和IV期卵巢癌乳头状浆液性癌病例组成的临床注释高密度组织芯片(HTMA)，探讨年龄与预后的相关性以及激素受体状态在年轻和老年患者中的意义。单因素分析显示，两组患者(年龄分别为65岁和70岁)的生存率下降，但不是多变量分析。在老年患者中，ER表达的可能性显著增加(p=0.01)，PR表达的可能性显著降低(p=0.02)。在整个研究人群中，ER和PR都不与生存率独立相关。确诊时年龄65岁的晚期乳头状浆液性卵巢癌患者的存活率与患者相似
Objective. Prior Studies have Suggested that patients diagnosed with ovarian cancer at an older age have Worse Outcomes. However, few Studies have examined whether differing patterns of protein expression in tumors in older patients correlate with this poorer prognosis. We investigated the correlation of age with prognosis and the significance of hormone receptor status in younger versus older patients through construction of a clinically-annotated high-density tissue microarray (HTMA) composed of stage III and IV papillary serous ovarian cancer cases.Methods. Two cohorts of patients (age >= 65 and = 70 years had decreased Survival On univariate, but not multivariate, analysis. ER was significantly more likely (p=0.01) and PR significantly less likely (p=0.02) to be expressed in older patients. Neither ER nor PR independently correlated with survival in the overall study population.Conclusions. Patients with advanced-stage papillary serous ovarian cancer >= 65 years of age at diagnosis have a similar Survival as patients