Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population.
Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population.
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DOI：
10.1016/j.dadm.2017.05.001
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Christian, Bradley T
中科院分区：
文献类型：
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作者：
Lao, Patrick J;Handen, Ben L;Christian, Bradley T
简介：唐氏综合症 (DS) 由 21 号染色体三倍体引起，导致淀粉样前体蛋白过度产生，并使个体易患早期阿尔茨海默病 (AD)。 方法：52 名患有 DS 的非痴呆成年人接受了两个周期的碳 11 标记匹兹堡化合物 B ([11C]PiB) 和 T1 加权磁共振成像 (MRI) 扫描，为期 3.0±0.6 年分开。标准摄取值比 (SUVR) 图像（50-70 分钟；小脑灰质 [GM]）和 GM 体积在标准化空间（蒙特利尔神经研究所空间）中进行分析。 结果：85% 的 PiB(-) 受试者仍保持 PiB(-)，而 15% 转化为 PiB(+)，主要在纹状体中。没有从 PiB(+) 恢复到 PiB(-)。 SUVR 的增长分布在全球范围内，但通用汽车的销量没有减少。 PiB 阳性组的 SUVR 变化百分比不同 [PiB(-)：0.5%/年，PiB 转换器：4.9%/年，PiB(+)：3.7%/年]，但 GM 体积没有差异。讨论：尽管具有特征性纹状体优先模式，但淀粉样蛋白累积的总体速率因预先存在的淀粉样蛋白负担而异，并且先于 DS 中的萎缩或痴呆人群，类似于一般 AD 进展。
INTRODUCTION: Down syndrome (DS) arises from a triplication of chromosome 21, causing overproduction of the amyloid precursor protein and predisposes individuals to early Alzheimer's disease (AD).METHODS: Fifty-two nondemented adults with DS underwent two cycles of carbon 11-labeled Pittsburgh compound B ([11C]PiB) and T1 weighted magnetic resonance imaging (MRI) scans 3.0±0.6years apart. Standard uptake value ratio (SUVR) images (50-70minutes; cerebellar gray matter [GM]) and GM volumes were analyzed in standardized space (Montreal Neurological Institute space).RESULTS: 85% of PiB(-) subjects remained PiB(-), whereas 15% converted to PiB(+), predominantly in the striatum. None reverted from PiB(+) to PiB(-). Increases in SUVR were distributed globally, but there were no decreases in GM volume. The PiB positivity groups differed in the percent rate of change in SUVR [PiB(-): 0.5%/year, PiB converters: 4.9%/year, and PiB(+): 3.7%/year], but not in GM volume.DISCUSSION: Despite the characteristic striatum-first pattern, the global rate of amyloid accumulation differs by pre-existing amyloid burden and precedes atrophy or dementia in the DS population, similar to general AD progression.