Estrogen receptor and breast cancer
Estrogen receptor and breast cancer
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DOI：
10.1006/scbi.2001.0389
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发表时间：
2001-10-01
影响因子：
14.5
通讯作者：
Fuqua, SAW
中科院分区：
文献类型：
--
作者：
Sommer, S;Fuqua, SAW
乳腺癌是女性中最常见的恶性肿瘤，早在一个多世纪前，人们就已经知道它与类固醇激素雌激素有关。雌激素受体（ER）的发现不仅为我们提供了一个强大的预测和预后标志物，而且为抗雌激素治疗激素依赖性乳腺癌提供了一个有效的靶点。在本文中，我们将概述内质网在疾病的发生，进展和治疗中的重要作用，这是复杂的受体与协调节蛋白的相互作用，它与其他信号转导途径的串扰，以及它参与抗雌激素抗性的发展。
Breast cancer, the most common malignancy in women, was already known to be associated with the steroid hormone estrogen more than a century ago. The discovery of the estrogen receptor (ER) provided us not only with a powerful predictive and prognostic marker, but also an efficient target for the treatment of hormone-dependent breast cancer with antiestrogens. In this paper we will sketch the important role of ER in the development, progression, and treatment of the disease, which is complicated by the receptor's interaction with coregulatory proteins, its cross-talk with other signal transduction pathways, and its involvement in the development of antiestrogen resistance.