Inflammatory clearance of apoptotic cells after UVB challenge
Inflammatory clearance of apoptotic cells after UVB challenge
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DOI：
10.1080/08916930701357125
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Kallenberg, Cees G. M.
中科院分区：
文献类型：
--
作者：
Bijl, Marc;Reefman, Esther;Kallenberg, Cees G. M.
在人体中，每天都会产生数十亿个凋亡细胞。去除这些细胞是必要的，以防止细胞内有毒成分的释放，并且通过（半）专职吞噬细胞的吞噬作用非常有效地发生。这种消除过程发生迅速，没有炎症。在系统性红斑狼疮（SLE）中，凋亡细胞的紊乱消除与疾病的诱导和再激活有关。凋亡细胞的积累可导致自身抗体的形成。延迟的促炎性清除也被认为在疾病表现后的炎性病变的发展中起关键作用。SLE患者的特征之一是暴露于阳光下时发生皮肤病变。在这篇综述中，我们将集中在凋亡细胞，他们的消除，和后果的干扰消除凋亡细胞的UVB诱导的炎症性皮肤病变的发展。
In the human body, every day billions of apoptotic cells are produced. Removal of these cells is necessary, to prevent the release of intracellular toxic constituents, and occurs very effectively via phagocytosis by (semi)- professional phagocytes. This elimination process occurs rapidly and without inflammation. In systemic lupus erythematosus (SLE) a disturbed elimination of apoptotic cells has been implicated in the induction and reactivation of the disease. Accumulation of apoptotic cells may result in autoantibody formation. A delayed, pro-inflammatory clearance is also thought to play a crucial role in the development of inflammatory lesions once the disease has manifested. One of the hallmarks of patients with SLE is the development of cutaneous lesions upon exposure to sunlight. In this review, we will focus on apoptotic cells, their elimination, and the consequences of a disturbed elimination of apoptotic cells on the development of UVB induced inflammatory skin lesions.