Combining depot antipsychotic with an assertive monitoring programme for treating first-episode schizophrenia in a resource-constrained setting
Combining depot antipsychotic with an assertive monitoring programme for treating first-episode schizophrenia in a resource-constrained setting
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DOI：
10.1111/eip.12141
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发表时间：
2016-02-01
影响因子：
2
通讯作者：
Emsley, Robin
中科院分区：
文献类型：
--
作者：
Chiliza, Bonginkosi;Ojagbemi, Akin;Emsley, Robin
目的评估长效抗精神病药（癸酸氟哌噻吨）联合主动监测计划 (AMP) 在首发精神分裂症中的可行性和有效性。方法这是一项为期 12 个月的前瞻性、非比较性纵向研究，评估患者的接受度、依从性、精神病理学领域的结果、功能和生活质量以及耐受性。结果在 207 名参与者中，149 名 (72%) 完成了治疗治疗12个月。对 Depot 的接受和遵守情况良好。 170 名参与者 (82%) 达到治疗反应，124 名参与者 (60%) 病情缓解。三十三名 (19%) 的反应者复发，10 名 (5%) 参与者符合治疗抵抗的先验标准。治疗总体耐受性良好。 结论 长效抗精神病药与 AMP 的组合可能是精神分裂症早期有效且安全的干预措施，并且可能特别适合资源有限的环境。
AimTo assess the feasibility and effectiveness of depot antipsychotic (flupenthixol decanoate) combined with an assertive monitoring programme (AMP) in first-episode schizophrenia.MethodsThis was a prospective, non-comparative, longitudinal study conducted over 12 months assessing patient acceptance, adherence, outcome in domains of psychopathology, functionality and quality of life, and tolerability.ResultsOf 207 participants, 149 (72%) completed 12 months of treatment. Acceptance of and adherence to depot was good. Treatment response was achieved by 170 (82%) participants and remission by 124 (60%). Thirty-three (19%) responders relapsed and 10 (5%) participants met a priori criteria for treatment resistance. Treatment was generally well tolerated.ConclusionsCombination of depot antipsychotic with an AMP may be an effective and safe intervention in early phases of schizophrenia, and may be particularly suitable for resource-constrained settings.