Out of the ER - outfitters, escorts and guides
Out of the ER - outfitters, escorts and guides
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DOI：
10.1016/s0962-8924(98)01414-7
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发表时间：
1999-01-01
影响因子：
19
通讯作者：
Schekman, R
中科院分区：
文献类型：
--
作者：
Herrmann, JM;Malkus, P;Schekman, R
内质网(ER)含有多种与分泌蛋白相互作用的特殊蛋白，促进它们进入高尔基体的运输小泡。这些辅助蛋白可能诱导和/或稳定分泌能力所需的构象，或者它们可能直接参与分泌蛋白的分选和摄取到高尔基体结合的小泡中。最近的努力旨在识别和表征这些底物特异的辅助蛋白中的几个的作用。
The endoplasmic reticulum (ER) contains a variety of specialized proteins that interact with secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi apparatus. These accessory proteins might induce and/or stabilize a conformation that is required for secretion competence or they might be directly involved in the sorting and uptake of secretory proteins into Golgi-bound vesicles. Recent efforts have aimed to identify and characterize the role of several of these substrate-specific accessory proteins.