RADIOACTIVE IRON AND ITS METABOLISM IN ANEMIA : ITS ABSORPTION, TRANSPORTATION, AND UTILIZATION.
RADIOACTIVE IRON AND ITS METABOLISM IN ANEMIA : ITS ABSORPTION, TRANSPORTATION, AND UTILIZATION.
复制标题
放射性铁及其在贫血中的代谢：其吸收，运输和利用。
DOI：
10.1084/jem.69.5.739
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发表时间：
1939-04-30
期刊：
影响因子：
--
通讯作者：
Whipple GH
中科院分区：
文献类型：
--
作者：
Hahn PF;Bale WF;Lawrence EO;Whipple GH
人工制造的放射性铁是一种极为敏感的物质，可用于跟踪铁在人体代谢过程中的变化，可用于研究铁的吸收、运输、交换、动员和排泄。人体对铁的需要以某种方式决定了这种元素的吸收。在正常狗体内，当不需要这种元素时，它的吸收量可以忽略不计。在贫血的动物体内，铁很快被吸收。血浆显然是铁从胃肠道运输到其动员点以形成血红蛋白的工具。铁的吸收和转移到红细胞的速度是惊人的。肝脏和骨髓在铁代谢中的重要性得到证实。
Artificially produced radioactive iron is an extremely sensitive agent for use in following iron in the course of its changes in body metabolism, lending itself to studies of absorption, transport, exchange, mobilization, and excretion. The need of the body for iron in some manner determines the absorption of this element. In the normal dog when there is no need for the element, it is absorbed in negligible amounts. In the anemic animal iron is quite promptly assimilated. The plasma is clearly the means of transport of iron from the gastrointestinal tract to its point of mobilization for fabrication into hemoglobin. The speed of absorption and transfer of iron to the red cell is spectacular. The importance of the liver and bone marrow in iron metabolism is confirmed.